Key result
Elevated hs-CRP and PCT lack independent predictive value for adverse outcomes compared to positive blood cultures.
Why the study?
Do perioperative PCT and hs-CRP levels predict adverse postoperative outcomes in surgical neonates?
Population
120 operated neonates admitted to surgical neonatal intensive care unit, 97% had congenital conditions…
Design
Cohort
Follow-up
until discharge or death
Authors
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Lower birth weight may associate with fewer severe complications; leaves open causal inference and requires prospective validation before clinical consideration.
Observational (n=120)
No
Do perioperative PCT and hs-CRP levels predict adverse postoperative outcomes in surgical neonates?
p-value: p=<0.001
While hs-CRP and PCT are sensitive markers for postoperative sepsis in surgical neonates, they are not independent predictors of adverse outcomes when adjusting for birth weight and blood culture positivity.
Ratan et al. (2026) conducted an observational in Neonatal sepsis in surgical neonates (n=120). Elevated serum procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) vs. Normal biomarker levels was evaluated on Adverse outcomes (Clavien-Dindo Grade 4 or death) (p=<0.001). Elevated hs-CRP and PCT correlated with adverse outcomes (P<0.001), but only lower birth weight and 24-hour blood culture positivity (OR 6.41; 95% CI 2.18-18.85) were independent predictors.
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