What is the clinical evidence from this study?

Study design: Observational. Population: HAdV-associated severe acute respiratory infection. Intervention: HAdV-B3 outbreak vs. Pre-outbreak period. Primary outcome: Clinical and genomic characteristics.

What question did this study set out to answer?

This study aims to characterize the clinical and genomic features of pediatric adenovirus-associated severe acute respiratory infections during an outbreak.

June 19, 2026International Journal of Infectious DiseasesOpen Access

Clinical and Genomic Characterization of Pediatric Adenovirus-Associated Severe Acute Respiratory Infection: A Binational Study from Brazil and Colombia, 2022–2023

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Key result

HAdV-B3 replaces HAdV-C as the dominant cause of severe acute respiratory infection.

Population

Hospitalized children with human adenovirus (HAdV)-associated severe acute respiratory infection

Design

Cohort

Authors

MMMaría Angélica MayaUniversidad Nacional de Colombia SRSonia M Raboni HGHeloisa I G Giamberardino

Discussion

Member takes

Implication

Alerts clinicians to post-NPI HAdV-B3 SARI risk in children; leaves open clade-specific severity differences.

Key Points

This study aims to characterize the clinical and genomic features of pediatric adenovirus-associated severe acute respiratory infections during an outbreak.
Multicenter observational study of hospitalized children with adenovirus-associated severe respiratory infection.
Respiratory samples underwent metagenomic sequencing and hexon gene analysis from February 2022 to April 2023.
Clinical and phylogenetic analyses evaluated viral dynamics and genetic diversity.
A significant adenovirus outbreak occurred in Curitiba, Brazil, and Antioquia, Colombia, during late 2022.
HAdV-C was predominant before the outbreak, while HAdV-B3 became the dominant genotype during the outbreak at both sites.
Distinct HAdV-B3 clades were identified, diverging from a shared ancestor but expanding independently in both countries.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Population

Hospitalized children with HAdV-associated severe acute respiratory infection in Brazil and Colombia evaluated between February 2022 and April 2023.

Outcome

Clinical and genomic characteristics, viral dynamics, and genetic diversity

Following the relaxation of non-pharmacological measures, Brazil and Colombia experienced a substantial rise in HAdV-B3-associated severe acute respiratory infections in children, driven by two distinct clades.

Cite This Study

Maya et al. (2026) conducted an observational in HAdV-associated severe acute respiratory infection. HAdV-B3 outbreak vs. Pre-outbreak period was evaluated on Clinical and genomic characteristics. The HAdV-B3 genotype became the dominant cause of HAdV-associated severe acute respiratory infection during a late 2022 outbreak in Brazil and Colombia, replacing the previously dominant HAdV-C.

synapsesocial.com/papers/6a35982fdd3be7785e70ecc1 https://doi.org/10.1016/j.ijid.2026.108893

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