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June 19, 2026Cardiology Research and PracticeOpen Access

TAVR vs. SAVR in Patients With Severe Aortic Stenosis and Chronic Kidney Disease Undergoing Dialysis: A Comprehensive Meta‐Analysis

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Key result

TAVR linked to ~51% lower in-hospital mortality vs SAVR in dialysis patients with severe aortic stenosis.

  • OR 0.49
  • 95% CI 0.29-0.84
  • P=0.01
  • n=28,625

Why the study?

Does TAVR improve postoperative clinical outcomes compared to SAVR in patients with severe AS and CKD undergoing dialysis?

Population

10 retrospective studies involving 28,625 patients with severe aortic stenosis and chronic kidney disease…

Comparison

Transcatheter aortic valve replacement (TAVR) vs Surgical aortic valve replacement (SAVR)

Design

Meta-analysis

Follow-up

in-hospital

Authors

MMManeeth MylavarapuNorthShore University HealthSystemMKMusa KiyaniServices Institute of Medical SciencesNTNiharika Tanwar

Discussion

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Implication

TAVR was associated with lower in-hospital mortality; leaves open selection bias and requires randomized confirmation before practice change.

Key Points

  • This study aims to compare the clinical outcomes of TAVR and SAVR in patients with severe aortic stenosis and chronic kidney disease undergoing dialysis.
  • Comprehensive search across databases including PubMed and EMBASE following PRISMA guidelines.
  • Inclusion of original studies comparing TAVR and SAVR outcomes in the specified patient population.
  • Analysis of 10 retrospective studies involving 28,625 patients (14,625 TAVR and 14,000 SAVR).
  • Patients undergoing TAVR had significantly lower odds of in-hospital mortality (OR 0.49; 95% CI 0.29, 0.84; p=0.01).
  • TAVR patients experienced shorter length of stay (SMD −2.59; 95% CI −5.04, −0.14; p≤0.04).
  • The TAVR group showed higher odds of permanent pacemaker implantation (OR 2.25; 95% CI 1.71–2.94; p<0.00001).

Study Design

Type

Meta-Analysis (n=28,625)

Structured PICO

Does TAVR improve postoperative clinical outcomes compared to SAVR in patients with severe AS and CKD undergoing dialysis?

P
Population
28,625 patients with severe aortic stenosis and chronic kidney disease undergoing dialysis from 10 retrospective studies comparing TAVR and SAVR.
I
Intervention
Transcatheter aortic valve replacement (TAVR)
C
Comparator
Surgical aortic valve replacement (SAVR)
O
Outcome
Postoperative clinical outcomes including in-hospital mortality, length of stay, and permanent pacemaker implantationhard clinical

Main Result

Odds Ratio: 0.49 (95% CI 0.29–0.84)

p-value: p=0.01

In patients with severe AS and CKD on dialysis, TAVR is associated with lower in-hospital mortality and shorter length of stay compared to SAVR, despite a higher risk of permanent pacemaker implantation.

Cite This Study

Mylavarapu et al. (2026) conducted a meta-analysis in Severe aortic stenosis and chronic kidney disease undergoing dialysis (n=28,625). Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated on in-hospital mortality (OR 0.49, 95% CI 0.29-0.84, p=0.01). TAVR was associated with significantly lower odds of in-hospital mortality compared to SAVR in patients with severe aortic stenosis and CKD on dialysis (OR 0.49; 95% CI 0.29-0.84; p=0.01).

synapsesocial.com/papers/6a358ddb3ed1b5ae34f8a78dhttps://doi.org/10.1155/crp/9451268
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