Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 18, 2026Biomedicine & PharmacotherapyOpen Access

Vericiguat attenuates arrhythmogenesis and diastolic tension in heart failure models via PKG and PKA pathways.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does vericiguat reduce pulmonary vein arrhythmogenesis in heart failure models?

Population

Isolated pulmonary vein myocytes and heart failure rabbits

Comparison

Vericiguat vs Control or pretreated with PKG inhibitor KT5823…

Design

Preclinical

Follow-up

4 weeks (in vivo)

Key result

Vericiguat significantly reduced pulmonary vein spontaneous activity and diastolic tension in heart failure models, attenuating arrhythmogenesis through PKG- and PKA-dependent mechanisms.

Authors

CCChao-Shun ChanYLYen‐Yu LuFLFong-Jhih Lin

Discussion

Loading...

Member takes

Overview

May support vericiguat's antiarrhythmic potential in HF; hypothesis-generating and requires clinical validation.

Key Points

  • This research investigates the effects of vericiguat on pulmonary vein arrhythmogenesis associated with heart failure.
  • Examined effects of vericiguat on PV action potential using microelectrodes.
  • Measured electrophysiological parameters in isolated PV myocytes with whole-cell patch-clamp.
  • Assessed calcium transients and content in myocytes through fluorescence imaging.
  • Vericiguat reduced PV spontaneous activity and diastolic tension; effects were PKG- and PKA-dependent.
  • It suppressed L-type calcium current and improved calcium transient and sarcoplasmic reticulum content.
  • Significant reduction in PV spontaneous activity observed in heart failure rabbits.

Structured PICO

Does vericiguat reduce pulmonary vein arrhythmogenesis in heart failure models?

P
Population
Isolated pulmonary vein myocytes and heart failure rabbits
I
Intervention
Vericiguat (0.1, 1, and 10 μM in vitro; 0.2 mg/kg intravenous 5 days/week for 4 weeks in vivo)
C
Comparator
Control (without vericiguat) or pretreated with PKG inhibitor KT5823 (1 μM) or PKA inhibitor H89 (10 μM)
O
Outcome
Pulmonary vein spontaneous activity and diastolic tensionsurrogate

Vericiguat attenuates pulmonary vein arrhythmogenesis in heart failure models through PKG- and PKA-dependent mechanisms, providing a potential mechanistic basis for antiarrhythmic benefits in HF.

Cite This Study

Chan et al. (2026) studied Heart failure and atrial fibrillation. Vericiguat vs. Without vericiguat was evaluated on Pulmonary vein spontaneous activity, diastolic tension, and electrical activity. Vericiguat significantly reduced pulmonary vein spontaneous activity and diastolic tension in heart failure models, attenuating arrhythmogenesis through PKG- and PKA-dependent mechanisms.

synapsesocial.com/papers/6a33cfcf14a9c556e6677922https://doi.org/10.1016/j.biopha.2026.119675
View Full Paper
Ask AI
Bookmark
Share