What is the clinical evidence from this study?

Study design: Cohort. Population: Atrial fibrillation (n=529). Intervention: SPISE index vs. Lower SPISE index. Primary outcome: Atrial fibrillation recurrence (HR 0.661, 95% CI 0.579-0.755, p=<0.001).

What does this research mean for the field?

The Single-Point Insulin Sensitivity Estimator (SPISE) index is a long-term predictor of atrial fibrillation recurrence in elderly patients following radiofrequency ablation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research examines how the SPISE index might predict recurring atrial fibrillation in elderly patients after treatment.

June 14, 2026Clinical Interventions in AgingOpen Access

A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

Q: What are the key findings of this study?

Q: What does this research mean for the field?

The Single-Point Insulin Sensitivity Estimator (SPISE) index is a long-term predictor of atrial fibrillation recurrence in elderly patients following radiofrequency ablation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This research examines how the SPISE index might predict recurring atrial fibrillation in elderly patients after treatment.

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Key result

A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

Authors

ZWZi Wang YQYilin Qu HWHua Wang

Discussion

Member takes

Overview

May support SPISE for post-ablation AF risk stratification in elderly patients; hypothesis-generating and requires prospective validation.

Key Points

This research examines how the SPISE index might predict recurring atrial fibrillation in elderly patients after treatment.
Investigated the association of the SPISE index with atrial fibrillation recurrence post-radiofrequency ablation.
Target population included elderly patients undergoing treatment for atrial fibrillation.
Higher SPISE index values were linked to a lower risk of atrial fibrillation recurrence post-ablation.
The study suggests a potential use of SPISE index as a prognostic tool in clinical settings.

Study Design

Type

Cohort (n=529)

Multicenter

PICO

Population

529 elderly patients aged 65 and older with atrial fibrillation who underwent radiofrequency ablation, evaluated for the association between baseline SPISE index and arrhythmia recurrence.

Exposure / Comparator

SPISE index vs Lower SPISE index

Primary Outcome

Atrial fibrillation recurrence — HR 0.661 (0.579-0.755), p=<0.001

Main Result

Hazard Ratio: 0.661 (95% CI 0.579–0.755)

p-value: p=<0.001

Limitations

Small sample size
Single-center retrospective design

Cite This Study

Wang et al. (2026) conducted a cohort in Atrial fibrillation (n=529). SPISE index vs. Lower SPISE index was evaluated on Atrial fibrillation recurrence (HR 0.661, 95% CI 0.579-0.755, p=<0.001). A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

synapsesocial.com/papers/6a2e4bc0b1cc60ccdea8caaf https://doi.org/10.2147/cia.s608687

View Full Paper

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June 14, 2026Clinical Interventions in AgingOpen Access

A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

View Full Paper

Ask AI

Bookmark

Key result

A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

Authors

ZWZi Wang YQYilin Qu HWHua Wang

Discussion

Member takes

Overview

May support SPISE for post-ablation AF risk stratification in elderly patients; hypothesis-generating and requires prospective validation.

Key Points

This research examines how the SPISE index might predict recurring atrial fibrillation in elderly patients after treatment.
Investigated the association of the SPISE index with atrial fibrillation recurrence post-radiofrequency ablation.
Target population included elderly patients undergoing treatment for atrial fibrillation.
Higher SPISE index values were linked to a lower risk of atrial fibrillation recurrence post-ablation.
The study suggests a potential use of SPISE index as a prognostic tool in clinical settings.

Study Design

Type

Cohort (n=529)

Multicenter

PICO

Population

529 elderly patients aged 65 and older with atrial fibrillation who underwent radiofrequency ablation, evaluated for the association between baseline SPISE index and arrhythmia recurrence.

Exposure / Comparator

SPISE index vs Lower SPISE index

Primary Outcome

Atrial fibrillation recurrence — HR 0.661 (0.579-0.755), p=<0.001

Main Result

Hazard Ratio: 0.661 (95% CI 0.579–0.755)

p-value: p=<0.001

Limitations

Small sample size
Single-center retrospective design

Cite This Study

synapsesocial.com/papers/6a2e4bc0b1cc60ccdea8caaf https://doi.org/10.2147/cia.s608687

View Full Paper

Ask AI

Bookmark