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June 14, 2026Biochemical and Biophysical Research CommunicationsOpen Access

MicroRNA-300-3p Promotes Cardiac Hypertrophy by Modulating the ACOX-1/GPX4 Pathway

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Authors

XLXiaojuan LiYWYanjia WangZYZiyao Yang

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Overview

Should not change hypertrophy management; hypothesis-generating for miR-300-3p/ACOX1/GPX4 targeting in remodeling.

Key Points

  • The aim is to explore how miR-300-3p influences cardiac hypertrophy through the ACOX1/GPX4 pathway.
  • In vitro assays to assess miR-300-3p effects on CH in response to angiotensin II (Ang II) stimulation.
  • Evaluation of ACOX1 expression changes with overexpression experiments.
  • Investigation of promoter hypomethylation effects mediated by DNMT1.
  • miR-300-3p promotes cardiac hypertrophy by targeting ACOX1, leading to increased ferroptosis.
  • Overexpression of ACOX1 significantly reduced hypertrophic responses.
  • DNMT1-mediated hypomethylation elevated miR-300-3p, enhancing Ang II-induced hypertrophic effects.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2e48b0b1cc60ccdea8ca7chttps://doi.org/10.1016/j.bbrc.2026.154145
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