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June 14, 2026MedCommOpen Access

Stearoyl‐CoA Desaturase‐1 Drives Tumor Growth by Interacting With Histone Deacetylase‐2 and Deacetylating Nucleophosmin‐1

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Authors

CWColine WéryLMLaetitia Montero‐RuizÉBÉric Bonneil

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Overview

SCD1 inhibition may enhance HDAC inhibitor sensitivity in cancer cells; leaves open clinical translation and patient outcomes.

Key Points

  • This research investigates the role of stearoyl-CoA desaturase-1 (SCD1) in cancer progression and its interaction with histone deacetylase-2 (HDAC2).
  • Analyzed SCD1 and its interaction with nucleophosmin-1 (NPM1) and HDAC2 under hypoxic conditions.
  • Examined the effects of SCD1 knockdown and pharmacological inhibition on cancer cell survival and response to HDAC inhibitors.
  • SCD1 was found to promote tumor growth through its interaction with NPM1 and HDAC2.
  • Knockdown of SCD1 or pharmacological inhibition increased sensitivity to HDAC inhibitors in cancer cells.

Cite This Study

Wéry et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46b3b1cc60ccdea8b625https://doi.org/10.1002/mco2.70809
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