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June 14, 2026European Heart Journal - Imaging Methods and PracticeOpen Access

High resolution, 3D isotropic late gadolinium enhanced imaging for the quantification of left atrial fibrosis and post-ablation scarring

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Authors

MFMaximilian FenskiRHRichard HicksteinLKLeo Dyke Krüger

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Overview

High-resolution 3D LGE Dixon enables LA fibrosis reference values in healthy subjects; leaves open its prognostic utility in AF cohorts.

Key Points

  • This study aims to assess the effectiveness of high-resolution 3D LGE imaging in quantifying left atrial fibrosis in atrial fibrillation patients and healthy controls.
  • Prospective study including 40 ablation-naïve AF patients and 20 healthy controls.
  • Patients underwent isotropic 3D whole-heart LGE imaging with a resolution of 1.3 mm³.
  • Fibrosis detection was validated against electroanatomical mapping and follow-up imaging at six months post ablation.
  • Persistent AF patients exhibited higher total LA enhancement than paroxysmal AF (3.65% vs. 1.16%, P=0.044) and controls (1.25%, P=0.041).
  • Fibrosis increased significantly in patients after follow-up from 1.68% to 6.30% (P<0.001), indicating ablation-induced scarring.
  • Intra-reader correlation for LA-LGE showed excellent reliability (ICC 0.99, 95% CI 0.95–0.99).

Cite This Study

Fenski et al. (2026) studied this question.

synapsesocial.com/papers/6a2e45d5b1cc60ccdea8ac23https://doi.org/10.1093/ehjimp/qyag100
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of Left Atrial Fibrosis With Cardiac <scp>MRI</scp>2025 · 1 citations
  2. 2Correlation between late gadolinium enhancement mri and high-definition electroanatomical voltage mapping for atrial fibrosis assessment across multiple thresholds2026
  3. 3Atrial Fibrosis Imaging: Correlation of Late Gadolinium Enhancement Magnetic Resonance Imaging With High‐Definition Voltage Electroanatomical Mapping Across Different Thresholds2026
  4. 4Preliminary Study of CMR Combined with Myocardial Strain Imaging for Left Atrial Fibrosis Assessment in Atrial Fibrillation Patients2025
  5. 5Unsupervised phenotyping of left atrial fibrosis patterns in universal atrial coordinates from 100 LGE MRI models2026