What question did this study set out to answer?

This research investigates how the triglyceride-glucose index and atherogenic cholesterol markers predict the risk of stroke.

June 14, 2026Scientific ReportsOpen Access

Joint association of triglyceride-glucose index and atherogenic lipid markers with incident stroke risk

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Why the study?

Do high triglyceride-glucose index and atherogenic lipid markers jointly increase the risk of incident stroke in middle-aged and older adults?

Population

8,544 middle-aged and older adults from the China Health and Retirement Longitudinal Study, mean age 59.0…

Comparison

High triglyceride-glucose index and high… vs Both TyG index and atherogenic cholesterol…

Design

Cohort

Follow-up

maximum 9.0 years

Authors

LYLaiang Yao GSGuiling Sun LZLanju Zhang

Discussion

Member takes

Implication

Combined TyG and atherogenic cholesterol markers may refine stroke risk stratification; leaves open whether this improves clinical decisions or outcomes.

Key Points

This research investigates how the triglyceride-glucose index and atherogenic cholesterol markers predict the risk of stroke.
Included 8,544 participants from the China Health and Retirement Longitudinal Study (CHARLS) with a mean age of 59 years.
Categorized participants based on median triglyceride-glucose index and cholesterol marker values, utilizing Cox proportional hazards models for analysis.
Employed receiver operating characteristic (ROC) curve analyses to examine predictive performance.
TyG index, non-HDL cholesterol, and remnant cholesterol are independently associated with increased stroke risk.
Participants with elevated levels of both TyG and non-HDL cholesterol had a stroke risk with HR of 1.76 (95% CI 1.41–2.20).
Adding these metabolic markers to traditional risk factors modestly improved stroke risk discrimination, with the highest AUC observed for combining TyG and non-HDL cholesterol.

Structured PICO

Do high triglyceride-glucose index and atherogenic lipid markers jointly increase the risk of incident stroke in middle-aged and older adults?

Population

8,544 middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS), mean age 59.0 years, 52.1% female. Excluded participants younger than 45 years and those with prevalent stroke or heart disease at baseline.

Intervention

High triglyceride-glucose (TyG) index and high atherogenic cholesterol markers (non-HDL cholesterol or remnant cholesterol) above median values

Comparator

Both TyG index and atherogenic cholesterol markers below median values

Outcome

First incident stroke during follow-up (ascertained through self-reported physician diagnosis)hard clinical

The combination of a high triglyceride-glucose index and high atherogenic cholesterol markers is independently and jointly associated with an increased risk of incident stroke, modestly improving risk discrimination beyond traditional risk factors.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6a2e45d5b1cc60ccdea8ab9c https://doi.org/10.1038/s41598-026-56940-5

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Implication

Combined TyG and atherogenic cholesterol markers may refine stroke risk stratification; leaves open whether this improves clinical decisions or outcomes.