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June 14, 2026Neurobiology of DiseaseOpen Access

Slow-wave–modulated high-frequency oscillations reveal early network abnormalities in pre-pathological 5XFAD mice

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Authors

PGPablo García-PeñaMRMilagros RamosJLJuan Manuel Montero López

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Overview

Early iEEG abnormalities in pre-plaque 5XFAD mice suggest network biomarkers; hypothesis-generating and leaves human translation open.

Key Points

  • The aim is to identify early electrophysiological markers of network dysfunction in the 5XFAD mouse model of Alzheimer's disease.
  • iEEG recordings from 5XFAD and wild-type mice at 1, 3-4, and 10-12 months of age.
  • Analysis of spectral power distribution, epileptiform activity, and phase-amplitude coupling (PAC).
  • Comparison of electrophysiological features in young, adult, and old mice.
  • Young 5XFAD mice displayed increased high-frequency oscillation (HFO) power and altered PAC with low-frequency rhythms.
  • Adult 5XFAD mice exhibited prominent epileptiform activity and seizures alongside spectral alterations.
  • Old 5XFAD mice showed no significant differences in iEEG features compared to controls.

Cite This Study

García-Peña et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4524b1cc60ccdea8a6adhttps://doi.org/10.1016/j.nbd.2026.107484
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