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June 14, 2026Frontiers in Cardiovascular MedicineOpen Access

Risk factors, subtype profiles, and outcomes of cardiac rupture after acute myocardial infarction: a case-control study

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Authors

DZDan ZhangCHChaojie HuangXWXiaosu Wang

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Overview

May support prioritizing emergency PCI to lower rupture risk; leaves open causality in observational data.

Key Points

  • This study aims to identify risk factors and outcomes associated with cardiac rupture following acute myocardial infarction.
  • Retrospective case-control study of 71 patients with cardiac rupture and 213 controls without complications from AMI.
  • Used multivariable logistic regression to identify factors associated with cardiac rupture.
  • Evaluated subtype comparisons and in-hospital mortality correlates.
  • Patients with cardiac rupture were significantly older (69.6 years) and had longer onset-to-door times.
  • Absence of emergency PCI (OR=8.23), female sex (OR=3.41), and low albumin levels (OR=0.84) were associated with increased risk of cardiac rupture.
  • Surgical repair significantly reduced in-hospital mortality (OR=0.06).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44a3b1cc60ccdea8a2b7https://doi.org/10.3389/fcvm.2026.1827832
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