What question did this study set out to answer?

The aim is to explore the issues surrounding normal saline use in critical care and its adverse effects.

June 13, 2026Exploration of MedicineOpen Access

Issues on the horizon of normal saline intravenous infusion in critical care medicine

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This review discusses the drawbacks of normal saline versus other physiological solutions, indicating potential health risks.

The aim is to explore the issues surrounding normal saline use in critical care and its adverse effects.
Reviewed recent studies comparing normal saline to other physiological solutions in critical care settings.
Identified potential harm associated with normal saline related to coagulopathy, metabolic acidosis, and AKI.
Normal saline is linked to hyperchloremia, metabolic acidosis, and higher mortality rates in ICU environments.
Excess chloride concentration in normal saline is identified as a primary factor for adverse outcomes.

Saad et al. (2026) studied this question.

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