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June 13, 2026Frontiers in NeurologyOpen Access

Menopause and ageing in women with multiple sclerosis

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Authors

CSCecilia Smith SimonsenECElisabeth Gulowsen Celius

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Overview

Narrative review explores menopause influence on disease activity and symptom burden in women with MS, suggesting complex interactions.

Key Points

  • This review investigates the relationship between menopause, biological ageing, and multiple sclerosis outcomes.
  • Narrative review based on structured literature search of PubMed
  • Supplemental reference screening for relevant studies
  • Current evidence does not support menopause as a distinct factor in relapse activity or MRI-defined inflammation.
  • Larger studies show no significant effect of menopause on EDSS progression when age is accounted for.
  • Symptom burden increases during midlife, influenced by hormonal changes and comorbidities.

Cite This Study

Simonsen et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f0556efhttps://doi.org/10.3389/fneur.2026.1838550
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunometabolic profiling in menopausal women with multiple sclerosis: the role of adipokines and hormone therapy2025
  2. 2Menopause and Inflammatory Bowel Disease: A Systematic Review2025
  3. 3Reproductive aging in biological females: mechanisms and immediate consequences2025 · 17 citations
  4. 4The role of menopause in cognitive disorders and Alzheimer’s disease2025
  5. 5Age at Menopause and Brain Atrophy Among Older Women2026