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To present a case of effective treatment for recurrent acute generalized pustular psoriasis (GPP) in a patient with multiple comorbidities.

June 13, 2026Frontiers in ImmunologyOpen Access

Breaking the barrier: oral tacrolimus plus apremilast rescues acute generalized pustular psoriasis with severe comorbidities—a case report

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To present a case of effective treatment for recurrent acute generalized pustular psoriasis (GPP) in a patient with multiple comorbidities.
Administered oral tacrolimus and apremilast to a 72-year-old female with a 10-year history of plaque psoriasis and recurrent GPP.
Monitored improvements in skin lesions and renal function after treatment.
Complete resolution of skin lesions observed after treatment.
Improvement in renal function noted, highlighting the potential for shared immunological mechanisms between GPP and chronic kidney disease.

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Case report shows resolution of symptoms in a patient with recurrent GPP and severe comorbidities, suggesting new treatment options.

L et al. (2026) studied this question.

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