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June 12, 2026European Journal of Preventive CardiologyOpen Access

Long QT syndrome in paediatric patients: a single-centre perspective

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Population

15 paediatric patients with Long QT syndrome followed up in a single-centre inherited arrhythmia clinic in a…

Design

Cohort

Follow-up

52.7 patient-years total

Key result

Among 15 paediatric patients with Long QT syndrome, 13.3% experienced an adverse cardiac event (syncope or ICD therapy) over 52.7 patient-years of follow-up.

Authors

MAM AbelaDCD CuschieriVGV Grech

Discussion

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Overview

Reassuring low event rate under follow-up supports current pediatric LQTS management; leaves open need for larger prospective cohorts.

Key Points

  • This research investigates the presentation and outcomes of long QT syndrome among paediatric patients.
  • Retrospective analysis of paediatric patients diagnosed with LQTS under 18 years.
  • Included individuals followed up in an inherited arrhythmia clinic.
  • Data analyzed using SPSS v23; significance set at p<0.05.
  • 67 patients diagnosed with LQTS, with 15 under 18 at diagnosis.
  • 73.3% of patients had QTc ≥500ms; 86.7% scored ≥3.5 on Schwartz score.
  • 13.3% experienced an event during 52.7 patient-years of follow-up, with no malignant arrhythmias recorded.

Study Design

Type

Observational (n=15)

Multicenter

No

Structured PICO

P
Population
15 paediatric patients (<18 years) with Long QT syndrome followed up in a single-center inherited arrhythmia clinic for a total of 52.7 patient-years.
O
Outcome
Presentation, penetrance, and outcomes (adverse cardiac events including syncope and ICD appropriate therapy)

Paediatric patients with LQTS display high penetrance and a non-benign clinical course, with frequent device implantation and adverse cardiac events.

Cite This Study

Abela et al. (2026) conducted an observational in Long QT syndrome (n=15). Long QT syndrome was evaluated on Adverse cardiac events (syncope or ICD appropriate therapy). Among 15 paediatric patients with Long QT syndrome, 13.3% experienced an adverse cardiac event (syncope or ICD therapy) over 52.7 patient-years of follow-up.

synapsesocial.com/papers/6a2bd1386550ea4541ffe9cehttps://doi.org/10.1093/eurjpc/zwag249.398
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Paediatric long QT syndrome: clinical outcomes and therapy in the Spanish National Registry2026 · 1 citations
  2. 2Beyond the Beat, Next-Generation Sequencing Discovery of Novel 2025
  3. 3Congenital long QT syndrome - can a 12-lead Holter ECG improve diagnosis?2026
  4. 4Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome2025
  5. 5[Electrocardiographic prediction parameters for life-threatening arrhythmic events in congenital long QT syndrome patients].2025