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June 12, 2026European Journal of Preventive CardiologyOpen Access

The between-group difference in change in peak VO2 at 12 weeks was 0.23 mL/kg/min (95% CI, -0.56 to 1.02; p=0.561).

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Why the study?

Does an app-based exercise support program improve peak oxygen uptake in patients with heart failure?

Population

100 patients with heart failure (all NYHA class I-II), median age 63 years, 13 females, in Japan.

Comparison

App-based exercise support program integrating… vs Standard exercise prescriptions.

Design

RCT, 1:1, open-label

Follow-up

24 weeks

Authors

YKY KatsumataKYK O K I YamaokaKDK Y O H E I Daigo

Discussion

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Overview

App-based exercise does not improve peak VO2 versus standard prescriptions in HF; challenges efficacy claims and leaves open adherence or durability questions.

Key Points

  • This trial aimed to assess the efficacy and safety of a wearable-integrated exercise app for heart failure patients.
  • Multicenter, open-label, randomized controlled trial across three university hospitals in Japan.
  • Patients with heart failure were assigned to either an app-based exercise program or standard exercise prescriptions.
  • Participants completed resistance training and maintained step goals over 24 weeks, with a primary endpoint of peak VO2 change.
  • Peak VO2 changes at 12 weeks showed no significant difference (0.23 mL/kg/min, 95% CI, −0.56 to 1.02; p=0.561).
  • Grip strength improvements were significant over 12 and 24 weeks in both groups.
  • In the per-protocol set, at 24 weeks, there was a significant difference in peak VO2 (0.93 mL/kg/min, 95% CI: 0.02 to 1.84; p=0.045).

Structured PICO

Does an app-based exercise support program improve peak oxygen uptake in patients with heart failure?

P
Population
100 patients with heart failure (all NYHA class I-II), median age 63 years, 13 females, in Japan.
I
Intervention
App-based exercise support program integrating wearable devices with real-time activity monitoring, interactive feedback, and algorithm-based goal setting. Included resistance training using video content 3 days per week and maintaining 2000-3000 steps per day at an intensity greater than target heart rate over 24 weeks.
C
Comparator
Standard exercise prescriptions.
O
Outcome
Change in peak oxygen uptake (VO2) at 12 weeks.surrogate

A wearable-integrated app-based exercise program did not significantly improve peak VO2 at 12 weeks compared to standard exercise prescriptions in patients with heart failure, though it may improve muscle strength.

Cite This Study

Katsumata et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd1386550ea4541ffe94chttps://doi.org/10.1093/eurjpc/zwag249.039
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