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June 12, 2026Clinical CardiologyOpen Access

Association of the TyG Index, Cardiometabolic Index, and Epicardial Adipose Tissue With Coronary Artery Disease

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Why the study?

Are the TyG index, cardiometabolic index, and epicardial adipose tissue index associated with the presence of coronary artery disease?

Population

180 individuals, comprising 120 patients with coronary artery disease and 60 age- and sex-matched controls.

Comparison

Assessment of triglyceride-glucose index… vs Age- and sex-matched controls without CAD.

Design

Case-control

Authors

JMJia MinZSZhai ShumeiZYZuo Yuqiang

Discussion

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Overview

TyG, CMI, and EATi were associated with CAD; leaves open incremental diagnostic value pending prospective validation.

Key Points

  • This study investigates how the TyG index, CMI, and EATi are associated with coronary artery disease (CAD) and explores metabolic pathways.
  • Included 120 CAD patients and 60 controls; evaluated clinical and biochemical data.
  • Calculated TyG index, CMI, and quantified EATi using CCTA; conducted correlation and logistic regression analyses.
  • Performed mediation and ROC analyses to assess pathways and diagnostic performance.
  • Fasting glucose, blood pressure, triglycerides, TyG, CMI, and EATi were significantly higher in CAD patients (all p < 0.05).
  • TyG (OR = 2.688, p = 0.002), CMI (OR = 3.339, p = 0.005), and EATi (OR = 2.284, p = 0.002) are independently associated with CAD.
  • Combined assessment of TyG, CMI, and EATi improved CAD diagnostic performance (AUC = 0.847).

Structured PICO

Are the TyG index, cardiometabolic index, and epicardial adipose tissue index associated with the presence of coronary artery disease?

P
Population
180 individuals, comprising 120 patients with coronary artery disease (CAD) and 60 age- and sex-matched controls.
I
Intervention
Assessment of triglyceride-glucose (TyG) index, cardiometabolic index (CMI), and epicardial adipose tissue index (EATi) quantified by coronary computed tomography angiography (CCTA).
C
Comparator
Age- and sex-matched controls without CAD.
O
Outcome
Association with coronary artery disease (CAD) and diagnostic performance.surrogate

The combined evaluation of TyG, CMI, and EATi improves the identification of coronary artery disease, highlighting distinct metabolic and adiposity-related mechanisms.

Cite This Study

Min et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe917https://doi.org/10.1002/clc.70375
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