What is the clinical evidence from this study?

Study design: Cohort. Population: Arrhythmogenic cardiomyopathy (n=163). Intervention: Higher exercise intensity vs. Lower exercise intensity. Primary outcome: Major ventricular arrhythmia, appropriate implantable cardioverter-defibrillator interventions, sudden cardiac arrest and sudden cardiac death.

What question did this study set out to answer?

This study aims to assess how exercise affects ECG progression in patients with arrhythmogenic cardiomyopathy (ACM).

June 12, 2026European Journal of Preventive CardiologyOpen Access

Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).

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Why the study?

Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?

Population

163 patients with a definitive diagnosis of arrhythmogenic cardiomyopathy or individuals harbouring a…

Comparison

Higher exercise exposure after diagnosis vs Lower exercise exposure after diagnosis

Design

Cohort

Follow-up

average 4.6±2.5 years

Key result

Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).

Authors

RSR Sriskandarajah TMT Cristina Minopoli ACA Canu

Discussion

Member takes

Overview

Exercise may modify ACM ECG progression; leaves open causality and optimal activity guidance pending trials.

Key Points

This study aims to assess how exercise affects ECG progression in patients with arrhythmogenic cardiomyopathy (ACM).
Retrospective analysis of clinical data from 202 patients with ACM, stratified into lower and higher exercise groups.
ECGs of 163 patients were analyzed at baseline and follow-up, focusing on key ECG abnormalities.
The primary composite endpoint included major ventricular arrhythmias and sudden cardiac events.
At baseline, 66% of patients had abnormal ECGs, with anterior T-wave inversion being the most common abnormality.
After an average follow-up of 4.6 years, 9% developed new abnormal ECG findings, with specific ECG changes not differing significantly by exercise group.
Higher exercise exposure post-diagnosis correlated with a greater prevalence of abnormal ECGs at follow-up (p=0.027).

Study Design

Type

Cohort (n=163)

Structured PICO

Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?

Population

163 patients with arrhythmogenic cardiomyopathy or associated pathogenic variants, followed for an average of 4.6 years.

Exposure

Higher exercise exposure (moderate and intense levels) after diagnosis

Comparator

Lower exercise exposure after diagnosis

Outcome

Composite of major ventricular arrhythmia, appropriate implantable cardioverter-defibrillator interventions, sudden cardiac arrest and sudden cardiac deathcomposite

Higher exercise exposure after diagnosis in patients with arrhythmogenic cardiomyopathy is associated with a greater prevalence of abnormal ECGs over time, supporting the need for regular ECG surveillance and individualized exercise recommendations.

Cite This Study

Sriskandarajah et al. (2026) conducted a cohort in Arrhythmogenic cardiomyopathy (n=163). Higher exercise intensity vs. Lower exercise intensity was evaluated on Major ventricular arrhythmia, appropriate implantable cardioverter-defibrillator interventions, sudden cardiac arrest and sudden cardiac death. Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe8b7 https://doi.org/10.1093/eurjpc/zwag249.386

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June 12, 2026European Journal of Preventive CardiologyOpen Access

Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).

View Full Paper

Ask AI

Bookmark

Why the study?

Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?

Population

163 patients with a definitive diagnosis of arrhythmogenic cardiomyopathy or individuals harbouring a…

Comparison

Higher exercise exposure after diagnosis vs Lower exercise exposure after diagnosis

Design

Cohort

Follow-up

average 4.6±2.5 years

Key result

Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).

Authors

RSR Sriskandarajah TMT Cristina Minopoli ACA Canu

Discussion

Member takes

Overview

Exercise may modify ACM ECG progression; leaves open causality and optimal activity guidance pending trials.

Key Points

This study aims to assess how exercise affects ECG progression in patients with arrhythmogenic cardiomyopathy (ACM).
Retrospective analysis of clinical data from 202 patients with ACM, stratified into lower and higher exercise groups.
ECGs of 163 patients were analyzed at baseline and follow-up, focusing on key ECG abnormalities.
The primary composite endpoint included major ventricular arrhythmias and sudden cardiac events.
At baseline, 66% of patients had abnormal ECGs, with anterior T-wave inversion being the most common abnormality.
After an average follow-up of 4.6 years, 9% developed new abnormal ECG findings, with specific ECG changes not differing significantly by exercise group.
Higher exercise exposure post-diagnosis correlated with a greater prevalence of abnormal ECGs at follow-up (p=0.027).

Study Design

Type

Cohort (n=163)

Structured PICO

Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?

Population

163 patients with arrhythmogenic cardiomyopathy or associated pathogenic variants, followed for an average of 4.6 years.

Exposure

Higher exercise exposure (moderate and intense levels) after diagnosis

Comparator

Lower exercise exposure after diagnosis

Outcome

Composite of major ventricular arrhythmia, appropriate implantable cardioverter-defibrillator interventions, sudden cardiac arrest and sudden cardiac deathcomposite

Cite This Study

synapsesocial.com/papers/6a2bd11d6550ea4541ffe8b7 https://doi.org/10.1093/eurjpc/zwag249.386

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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