What is the clinical evidence from this study?

Study design: Observational. Population: Atrial Fibrillation (n=864). Intervention: Physical activity vs. Lower physical activity. Primary outcome: Time to onset of first AF episode lasting ≥6 minutes occurring within the first 3 years (HR 0.937, 95% CI 0.835-1.050, p=0.263).

What question did this study set out to answer?

This analysis explores how physical activity, measured objectively, relates to atrial fibrillation occurrence detected by implantable loop recorders.

June 12, 2026European Journal of Preventive CardiologyOpen Access

Physical activity duration was not associated with an increased risk of incident atrial fibrillation detected on implantable loop recorder (HR 0.937; 95% CI 0.835-1.050; P=0.263).

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Why the study?

Does physical activity level affect the risk of incident atrial fibrillation detected on implantable loop recorder in men without prior AF?

Population

864 men with no history or symptoms of atrial fibrillation, comprising male veteran cyclists/triathletes and…

Comparison

Physical activity measured by accelerometer from… vs Lower levels of physical activity

Design

Cohort

Follow-up

3 years

Key result

Physical activity duration was not associated with an increased risk of incident atrial fibrillation detected on implantable loop recorder (HR 0.937; 95% CI 0.835-1.050; P=0.263).

Authors

BCB Chambers SDS Z Diederichsen WJW Javed

Discussion

Member takes

Overview

No increased AF risk after adjustment in athletes; leaves open dose-response effects in larger cohorts.

Key Points

This analysis explores how physical activity, measured objectively, relates to atrial fibrillation occurrence detected by implantable loop recorders.
Included male participants from VENTOUX (n=106) and LOOP (n=758) studies, with no history of AF.
Measured physical activity over follow-up using accelerometer data from ILR.
Conducted Cox regression analysis adjusted for CHARGE-AF score.
31% of participants developed AF, with only 7% experiencing symptoms.
No significant association between physical activity hours/day and AF incidence (HR 0.937, 95% CI 0.835-1.050, p=0.263).
Higher physical activity was associated with increased symptom presentation among AF patients (OR 9.29, 95% CI 1.55-55.78, p=0.015).

Study Design

Type

Observational (n=864)

Multicenter

Yes

Structured PICO

Does physical activity level affect the risk of incident atrial fibrillation detected on implantable loop recorder in men without prior AF?

Population

864 male participants without prior atrial fibrillation, including veteran athletes and asymptomatic individuals with a stroke risk factor, monitored via implantable loop recorder for 3 years.

Exposure

Physical activity measured by accelerometer from implantable loop recorder (ILR)

Comparator

Lower levels of physical activity (e.g., 0-1 hours per day)

Outcome

Time to onset of first AF episode lasting ≥6 minutes occurring within the first 3 yearshard clinical

Main Result

Hazard Ratio: 0.937 (95% CI 0.835–1.05)

p-value: p=0.263

Physical activity level was not associated with incident AF detected on ILR, but higher physical activity was associated with a greater likelihood of being symptomatic at AF onset.

Cite This Study

Chambers et al. (2026) conducted an observational in Atrial Fibrillation (n=864). Physical activity vs. Lower physical activity was evaluated on Time to onset of first AF episode lasting ≥6 minutes occurring within the first 3 years (HR 0.937, 95% CI 0.835-1.050, p=0.263). Physical activity duration was not associated with an increased risk of incident atrial fibrillation detected on implantable loop recorder (HR 0.937; 95% CI 0.835-1.050; P=0.263).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe86d https://doi.org/10.1093/eurjpc/zwag249.395

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June 12, 2026European Journal of Preventive CardiologyOpen Access

Physical activity duration was not associated with an increased risk of incident atrial fibrillation detected on implantable loop recorder (HR 0.937; 95% CI 0.835-1.050; P=0.263).

View Full Paper

Ask AI

Bookmark

Why the study?

Does physical activity level affect the risk of incident atrial fibrillation detected on implantable loop recorder in men without prior AF?

Population

864 men with no history or symptoms of atrial fibrillation, comprising male veteran cyclists/triathletes and…

Comparison

Physical activity measured by accelerometer from… vs Lower levels of physical activity

Design

Cohort

Follow-up

3 years

Key result

Physical activity duration was not associated with an increased risk of incident atrial fibrillation detected on implantable loop recorder (HR 0.937; 95% CI 0.835-1.050; P=0.263).

Authors

BCB Chambers SDS Z Diederichsen WJW Javed

Discussion

Member takes

Overview

No increased AF risk after adjustment in athletes; leaves open dose-response effects in larger cohorts.

Key Points

This analysis explores how physical activity, measured objectively, relates to atrial fibrillation occurrence detected by implantable loop recorders.
Included male participants from VENTOUX (n=106) and LOOP (n=758) studies, with no history of AF.
Measured physical activity over follow-up using accelerometer data from ILR.
Conducted Cox regression analysis adjusted for CHARGE-AF score.
31% of participants developed AF, with only 7% experiencing symptoms.
No significant association between physical activity hours/day and AF incidence (HR 0.937, 95% CI 0.835-1.050, p=0.263).
Higher physical activity was associated with increased symptom presentation among AF patients (OR 9.29, 95% CI 1.55-55.78, p=0.015).

Study Design

Type

Observational (n=864)

Multicenter

Yes

Structured PICO

Does physical activity level affect the risk of incident atrial fibrillation detected on implantable loop recorder in men without prior AF?

Population

864 male participants without prior atrial fibrillation, including veteran athletes and asymptomatic individuals with a stroke risk factor, monitored via implantable loop recorder for 3 years.

Exposure

Physical activity measured by accelerometer from implantable loop recorder (ILR)

Comparator

Lower levels of physical activity (e.g., 0-1 hours per day)

Outcome

Time to onset of first AF episode lasting ≥6 minutes occurring within the first 3 yearshard clinical

Main Result

Hazard Ratio: 0.937 (95% CI 0.835–1.05)

p-value: p=0.263

Physical activity level was not associated with incident AF detected on ILR, but higher physical activity was associated with a greater likelihood of being symptomatic at AF onset.

Cite This Study

synapsesocial.com/papers/6a2bd11d6550ea4541ffe86d https://doi.org/10.1093/eurjpc/zwag249.395

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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