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June 12, 2026European Journal of Preventive CardiologyOpen Access

Association of body composition with clinical variables and mortality in heart failure patients with preserved and reduced systolic function

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Key result

Decreases in BMI (r=-0.343; p=0.032) and total body fat mass (r=-0.324; p=0.039) were significantly correlated with increased overall mortality in patients with compensated heart failure.

Why the study?

Is body composition associated with clinical variables and mortality in patients with compensated heart failure?

Population

54 compensated (NYHA I, II) heart failure patients, divided into HFpEF (EF ≥45%) and HFrEF (EF <45%)

Design

Cohort

Authors

FMF MolnarMRM RabaiDCD Czencz

Discussion

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Overview

Supports cautious weight management in obese HF; extends observational data on obesity paradox without practice change.

Key Points

  • The study aimed to identify clinical parameters differentiating HFrEF and HFpEF patients and their impact on mortality.
  • Enrolled 54 compensated heart failure patients categorized into HFpEF and HFrEF based on ejection fraction.
  • Assessed nutritional status using BMI and bioimpedance analysis for body composition.
  • Conducted laboratory tests for routine biomarkers and analyzed data using Mann–Whitney U test and Pearson correlation.
  • BMI was significantly higher in HFpEF patients (26.548 ± 3.912 vs. 31.839 ± 8.992; p=0.026).
  • NT-proBNP levels were significantly higher in HFrEF patients (5295.930 ± 5890.349 vs. 1813.870 ± 3156.359; p=0.008).
  • Decreases in BMI (r = –0.343; p=0.032) and total body fat mass (r = –0.324; p=0.039) correlated significantly with increased mortality.

Study Design

Type

Observational (n=54)

Structured PICO

Is body composition associated with clinical variables and mortality in patients with compensated heart failure?

P
Population
54 compensated (NYHA I, II) heart failure patients with preserved or reduced ejection fraction.
O
Outcome
Clinical parameters (BMI, body composition, NT-proBNP) and overall mortalityhard clinical

Main Result

Effect estimate: r = -0.343

p-value: p=0.032

In patients with heart failure, a decrease in BMI and total body fat mass is associated with increased mortality, supporting the obesity paradox.

Cite This Study

Molnar et al. (2026) conducted an observational in Heart failure (n=54). Decreased BMI and body fat mass was evaluated on overall mortality (r = -0.343, p=0.032). Decreases in BMI (r=-0.343; p=0.032) and total body fat mass (r=-0.324; p=0.039) were significantly correlated with increased overall mortality in patients with compensated heart failure.

synapsesocial.com/papers/6a2bd1056550ea4541ffe85bhttps://doi.org/10.1093/eurjpc/zwag249.053
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