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June 7, 2026Journal of Medical BiochemistryOpen Access

Serum TRF and LGP2 levels in patients with CHD were significantly decreased compared to controls (P<0.05) and were negatively correlated with BNP, CK-MB, LVESD, LVEDD, LV mass, and IVS, and positively correlated with LVEF and CO (P<0.05).

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Population

252 patients with coronary heart disease and 240 healthy controls.

Design

Case-control

Authors

TCTianhao CuiSZShuai ZhaoYXYing Xia

Discussion

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Overview

Serum TRF and LGP2 levels are significantly decreased in patients with coronary heart disease and correlate strongly with worsening cardiac function and structural remodeling.

Key Points

  • This research aims to investigate the relationship between serum TRF and LGP2 levels and cardiac function in patients with coronary heart disease (CHD).
  • Evaluated 252 patients with CHD and 240 healthy controls from October 2023 to October 2025.
  • Measured serum levels of TRF, LGP2, BNP, and CK-MB using enzyme-linked immunosorbent assays (ELISA).
  • Analyzed cardiac function using Doppler ultrasound and Pearson correlation for TRF and LGP2 levels against cardiac function markers.
  • Patients with CHD had significantly lower TRF and LGP2 levels compared to controls (P<0.05).
  • Higher NYHA grades showed significantly lower LVEF and CO, along with lower TRF and LGP2 levels (P<0.05).
  • Negative correlations were found between TRF and LGP2 levels and BNP, CK-MB, LVESD, LVEDD, LV mass, and IVS (P<0.05).

Structured PICO

P
Population
252 patients with coronary heart disease (CHD) (72 NYHA class II, 124 NYHA class III, 56 NYHA class IV) and 240 healthy controls.
C
Comparator
240 healthy patients who had physical examinations at the same institution
O
Outcome
Correlation between serum TRF and LGP2 levels and cardiac function markers (BNP, CK-MB, LVEF, LVESD, LVEDD, CO, IVS, LV mass)surrogate

Serum TRF and LGP2 levels are significantly decreased in patients with coronary heart disease and correlate strongly with worsening cardiac function and structural remodeling.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a250c7d7def13d035e1caadhttps://doi.org/10.5937/jomb0-66239
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