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June 7, 2026Cardiovascular TherapeuticsOpen Access

Real‐World Antithrombotic Management of Nonvalvular Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention in China: A Cross‐Sectional Study

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Why the study?

What are the real-world antithrombotic management strategies in Chinese patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention?

Population

1,306 patients with a confirmed diagnosis of nonvalvular atrial fibrillation undergoing percutaneous…

Design

Cross-sectional

Authors

JYJiwei YuSLShuolin LiuRDRun Du

Discussion

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Overview

There is a substantial gap between guideline recommendations and real-world practice in Chinese AF patients undergoing PCI, characterized by an overreliance on DAPT and underutilization of oral anticoagulants.

Key Points

  • This research examines the antithrombotic management practices for patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention in Shanghai, China.
  • Cross-sectional analysis of data from the Shanghai Cardiac Intervention Quality Control Center, focusing on 1306 NVAF patients.
  • Evaluation of antithrombotic regimens, including dual antiplatelet therapy and oral anticoagulants.
  • Comparison of demographic and clinical characteristics across different antithrombotic strategy groups.
  • Dual antiplatelet therapy was the most common regimen, used by 44.7% of enrolled patients.
  • Only 55.8% of male and 55.6% of female patients with elevated CHA2DS2-VASc scores received anticoagulation therapy.
  • Patients on oral anticoagulants had significantly higher rates of persistent AF (53.2% vs. 33.9%, p < 0.001).

Structured PICO

What are the real-world antithrombotic management strategies in Chinese patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention?

P
Population
1,306 patients with a confirmed diagnosis of nonvalvular atrial fibrillation (NVAF) undergoing percutaneous coronary intervention (PCI) across 36 centers in Shanghai, China.
I
Intervention
Real-world antithrombotic therapy strategies (including dual antiplatelet therapy [DAPT] and oral anticoagulants [OACs])
O
Outcome
Proportion of patients receiving different antithrombotic regimens (e.g., DAPT, OACs)

There is a substantial gap between guideline recommendations and real-world practice in Chinese AF patients undergoing PCI, characterized by an overreliance on DAPT and underutilization of oral anticoagulants.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a250c3b7def13d035e1c4a9https://doi.org/10.1155/cdr/5163410
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