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June 7, 2026Diabetes

Mean cfPWV (6.2±0.2 m/s) did not differ by group and was not associated with glucose or IR markers, but was significantly associated with age (β=0.15 m/s, P<0.01) and total fat mass (β=2.9×10-3, P<0.01).

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Why the study?

Is arterial stiffness associated with insulin resistance and glucose responses in youth-onset type 2 diabetes?

Population

27 participants (20 with youth-onset type 2 diabetes and 7 healthy peers), mean age 20±3 years, 56% female.

Design

Cohort

Authors

MGMADILYN M. GAYDOSIKILA N. KACKERSCSAMSON L. CANTOR

Discussion

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Overview

In youth, fat mass and age, rather than glucose or insulin measures, appear to be the primary drivers of arterial stiffness.

Key Points

  • The research aims to understand how accelerated vascular aging in youth-onset type 2 diabetes is related to insulin resistance and glucose responses.
  • Prospective analysis involving 20 youth-onset type 2 diabetes and 7 healthy peers
  • Arterial stiffness measured using carotid-femoral pulse wave velocity and augmentation index after a 12-hour fast
  • Insulin resistance assessed using Matsuda Index and HOMA-IR
  • Participants with youth-onset type 2 diabetes had higher BMI, HbA1c, and total fat mass (P<0.01)
  • Mean carotid-femoral pulse wave velocity did not differ significantly between groups and showed no association with insulin resistance or glucose markers
  • Age was the strongest predictor of arterial stiffness, with fat mass indicating a potential relationship

Structured PICO

Is arterial stiffness associated with insulin resistance and glucose responses in youth-onset type 2 diabetes?

P
Population
27 participants (20 with youth-onset type 2 diabetes and 7 healthy peers), mean age 20±3 years, 56% female.
O
Outcome
Arterial stiffness measured as carotid-femoral pulse wave velocity (cfPWV) and augmentation index at heart rate 75 (AIx75)surrogate

In youth, fat mass and age, rather than glucose or insulin measures, appear to be the primary drivers of arterial stiffness.

Cite This Study

GAYDOS et al. (2026) studied this question.

synapsesocial.com/papers/6a250b8b7def13d035e1b8a5https://doi.org/10.2337/db26-2081-p
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