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June 7, 2026Diabetes

The change in MAGE did not differ significantly between usual care and Standardized (p=0.24), usual care and Personalized (p=0.13), or Standardized and Personalized (p=0.70).

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Why the study?

Does a personalized or standardized Mediterranean diet telemedicine intervention improve glycemic variability in adults with moderately controlled type 2 diabetes?

Population

161 U.S. adults (21-80 years) with moderately controlled T2D (HbA1c 6.5-8.0%), mean age 60, 62.7% female.

Comparison

Personalized intervention or Standardized… vs Usual care control (UCC).

Design

RCT, 3-arm randomized controlled trial

Follow-up

6 months

Authors

LBLAUREN BERUBECWCHAN WANGMCMargaret Curran

Discussion

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Overview

A 6-month fully remote precision nutrition intervention using real-time feedback did not improve most glycemic variability indices beyond usual care or standard Mediterranean diet counseling in moderately controlled T2D.

Key Points

  • The study aims to assess the effectiveness of personalized dietary management on glycemic control in individuals with type 2 diabetes.
  • Conducted as a fully remote, 6-month, 3-arm randomized controlled trial.
  • Participants aged 21-80 years with moderately controlled type 2 diabetes (HbA1c 6.5-8.0%) received either usual care, a standardized intervention, or a personalized intervention.
  • Glycemic variability metrics were measured using continuous glucose monitoring at baseline, 3 months, and 6 months.
  • No significant differences in mean amplitude of glycemic excursions (MAGE) among the three arms (UCC vs Standardized p=0.24, UCC vs Personalized p=0.13, Standardized vs Personalized p=0.70).
  • At 6 months, the Personalized intervention showed a greater reduction in the coefficient of variation (CV) compared to Usual Care (mean difference: −1.84%; 95% CI: −3.57 to −0.11; p=0.04).
  • Most glycemic variability metrics did not differ significantly among intervention arms.

Structured PICO

Does a personalized or standardized Mediterranean diet telemedicine intervention improve glycemic variability in adults with moderately controlled type 2 diabetes?

P
Population
161 U.S. adults (21-80 years) with moderately controlled T2D (HbA1c 6.5-8.0%), mean age 60, 62.7% female.
I
Intervention
Personalized intervention (14 behavioral counseling sessions on Mediterranean diet-based diabetes self-management plus real-time, algorithm-driven feedback on predicted postprandial glycemic response) or Standardized intervention (14 counseling sessions only) over 6 months.
C
Comparator
Usual care control (UCC).
O
Outcome
Change in glycemic variability metrics, including mean amplitude of glycemic excursions (MAGE), at 3 and 6 months.surrogate

A 6-month fully remote precision nutrition intervention using real-time feedback did not improve most glycemic variability indices beyond usual care or standard Mediterranean diet counseling in moderately controlled T2D.

Cite This Study

BERUBE et al. (2026) studied this question.

synapsesocial.com/papers/6a250b0e7def13d035e1b057https://doi.org/10.2337/db26-2783-lb
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