Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
This research is Trending!
June 6, 2026BMC MedicineOpen Access

Single-nucleus transcriptomic profiling of 525 cardiac samples identified a cardiomyocyte-like fibroblast subpopulation and revealed distinct stage-specific remodeling trajectories in HCM and DCM.

View Full Paper
Ask AI
Bookmark
Share

Population

525 cardiac tissue samples spanning dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic…

Comparison

Single-nucleus transcriptomic profiling and… vs Non-failing controls

Design

Preclinical

Key result

Single-nucleus transcriptomic profiling of 525 cardiac samples identified a cardiomyocyte-like fibroblast subpopulation and revealed distinct stage-specific remodeling trajectories in HCM and DCM.

Authors

QTQianzi TangXLXingyu LiXFXiongwei Fan

Discussion

Loading...

Member takes

Overview

May guide phenotype-specific cardiomyopathy therapies; leaves open translation from animal models to human practice.

Key Points

  • The study aims to define cell-type-specific mechanisms and differences in cardiomyopathies through a comprehensive transcriptomic atlas.
  • Analyzed 525 cardiac tissue samples, integrating over 2 million single nuclei from various cardiomyopathy types and controls.
  • Identified distinct fibroblast subpopulations and their remodeling roles in dilated and hypertrophic cardiomyopathies.
  • Mapped dynamic changes in cellular signaling at different disease stages.
  • Identified a fibroblast subpopulation expressing cardiomyopathy genes, with reparative potential in specific states.
  • HCM showed compensatory hypertrophic remodeling, while DCM exhibited cardiomyocyte loss and maladaptive fibroblast expansion.
  • LVEF-associated pseudotime staging highlighted dynamic remodeling processes differing between early HCM and DCM.

Study Design

Type

Observational (n=525)

Structured PICO

P
Population
525 cardiac tissue samples spanning dilated, hypertrophic, arrhythmogenic right ventricular, and left ventricular non-compaction cardiomyopathies, alongside non-failing controls.
E
Exposure
Single-nucleus transcriptomic profiling and integration (Cardiac Cell Atlas)
C
Comparator
Non-failing controls
O
Outcome
Cell-type-specific mechanisms, shared remodeling signatures, and divergent trajectories across cardiomyopathiessurrogate

A large-scale single-nucleus transcriptomic atlas of human cardiomyopathies reveals a novel cardiomyocyte-like fibroblast subpopulation and distinct stage-specific remodeling trajectories in HCM and DCM.

Trending Research#1 this week

Published June 5, 2026; high social shares among cardiologists; rapid citations in preprints.

Social attention
85
Preprint velocity
70
News coverage
60
Conference
50
Expert commentary
80

Cite This Study

Tang et al. (2026) conducted an observational in Cardiomyopathies (n=525). Cardiomyopathy vs. Non-failing controls was evaluated on Cell-type-specific mechanisms and remodeling trajectories. Single-nucleus transcriptomic profiling of 525 cardiac samples identified a cardiomyocyte-like fibroblast subpopulation and revealed distinct stage-specific remodeling trajectories in HCM and DCM.

synapsesocial.com/papers/6a23bf1671a5da9775e77cd4https://doi.org/10.1186/s12916-026-04954-1
View Full Paper
Ask AI
Bookmark
Share