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June 6, 2026DermatoOpen Access

The Use of JAK Inhibitors in AD Affecting Difficult-to-Treat Areas: Lessons from Real-Life

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Authors

DCDaniele CecereGLGiuseppe LaulettaLPLuca Potestio

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Overview

Structured review synthesizes real-world evidence showing JAK inhibitors improve outcomes in atopic dermatitis affecting complex regions, suggesting effective treatment options.

Key Points

  • This review aims to compile real-world evidence on the effectiveness of JAK inhibitors in treating atopic dermatitis in difficult anatomical regions.
  • Conducted a comprehensive search of multiple databases including PubMed and Embase up to December 2025.
  • Included observational studies reporting outcomes for atopic dermatitis treated with JAK inhibitors in challenging areas.
  • Excluded primary randomized controlled trial efficacy analyses, focusing on relevant post hoc regional analyses.
  • JAK inhibitors showed clinically meaningful improvements in difficult regions like the head and neck, and hands.
  • Rapid reduction in pruritus was consistently observed across studies.
  • Safety profiles were generally consistent with existing clinical trial data.

Cite This Study

Cecere et al. (2026) studied this question.

synapsesocial.com/papers/6a23ba1771a5da9775e75cc2https://doi.org/10.3390/dermato6020021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Use of JAK Inhibitors in Elderly Patients with Moderate-to-Severe Atopic Dermatitis: A Narrative Review of Clinical and Real-World Evidence2025
  2. 2Upadacitinib Leads in Efficacy: A Bayesian Network Meta‐Analysis of Four <scp>JAK</scp> Inhibitors in Moderate‐To‐Severe Atopic Dermatitis2026
  3. 3[Progress in the application of JAK inhibitors in atopic dermatitis].2025
  4. 4Comparative short-term efficacy of Janus kinase 1 inhibitors and anti-interleukin-13 antibodies in atopic dermatitis: a retrospective cohort analysis based on real-world data2025 · 1 citations
  5. 5Real‐World Effectiveness and Safety of <scp>JAK</scp> Inhibitors in Atopic Dermatitis: A Systematic Review and Meta‐Analysis2025