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June 6, 2026Clinical and Experimental MedicineOpen Access

Venetoclax, azacitidine, and chidamide in combination with cytarabine, aclarubicin, and G-CSF as induction chemotherapy for myelodysplasia-related acute myeloid leukemia

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Authors

LLLei LvJYJingjing YangQLQingyang Liu

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Overview

Retrospective study shows superior outcomes in AML patients using CACAG-VEN regimen, suggesting benefits over standard treatment.

Key Points

  • This study aims to evaluate the efficacy and safety of the CACAG-VEN regimen in treating AML-MR.
  • Retrospective analysis of 30 AML-MR patients treated with CACAG-VEN from 2023 to 2024.
  • Cohort comparison with 30 patients receiving standard '3 + 7' regimen from 2018 to 2022.
  • Primary endpoint was complete remission rate after one induction cycle.
  • CACAG-VEN achieved a complete remission rate of 83.3% (95% CI, 66.4-92.7).
  • 1-year overall survival for CACAG-VEN was 90.0% (95% CI: 72.1-96.7).
  • CACAG-VEN showed superior response rates compared to '3 + 7' regimen (CR: 55.7%, p = 0.003).

Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/6a23b96a71a5da9775e754dchttps://doi.org/10.1007/s10238-026-02200-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Venetoclax-azacitidine in combination with chidamide and CAG versus daunorubicin and cytarabine in newly diagnosed AML2025
  2. 2Safety and efficacy of venetoclax plus CAG (cytarabine, aclarubicin, G-CSF) regimen in patients with relapsed or refractory Acute Myeloid Leukemia: A prospective single-arm phase II study2025
  3. 3[Clinical Efficacy of CAG Regimen Combined with Venetoclax, Chidamide, and Azacitidine in the Treatment of Elderly Patients with Acute Myeloid Leukemia].2025
  4. 4Reduced intensive chemotherapy combined with venetoclax in adult patients with Acute Myeloid Leukemia: A retrospective single-center analysis2025
  5. 5Predictive significance of early bone marrow MRD response assessment in Acute Myeloid Leukemia patients treated with venetoclax plus decitabine induction therapy: Real-world data from India2025