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Evaluate the efficacy and safety of intralesional vitamin D compared to triamcinolone acetonide in keloid treatment.

June 6, 2026Frontiers in MedicineOpen Access

Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials

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Evaluate the efficacy and safety of intralesional vitamin D compared to triamcinolone acetonide in keloid treatment.
Systematic review and meta-analysis of randomized controlled trials
Search conducted on PubMed, Embase, and Cochrane library
Primary outcome was scar improvement using validated scales
Triamcinolone acetonide improved scar severity (MD = −9.72; 95% CI -17.41 to −2.02; p = 0.013) and lesion flattening (RR = 0.68; 95% CI 0.48 to 0.96; p = 0.028)
Vitamin D reduced risks of pigmentation changes (RR = 0.23; 95% CI 0.07 to 0.78; p = 0.018) and skin atrophy (RR = 0.51; 95% CI 0.32 to 0.82; p = 0.006)
TAC was more effective in scar regression, while vitamin D had a favorable safety profile.

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Randomized trial compares vitamin D and triamcinolone acetonide for keloids, revealing safety and efficacy differences.

Jiang et al. (2026) studied this question.

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