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May 31, 2026Open Access

Genome-Wide Dna Methylation Patterns Associated With Blood Pressure Traits in People With Hiv

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Randomized trial examines blood pressure changes in people with HIV, revealing important epigenetic mechanisms.

This research aims to identify DNA methylation patterns associated with blood pressure traits in people with HIV.
Conducted cross-sectional and longitudinal methylome-wide association studies (MWAS) of blood pressure traits in PWH exposed to ART.
Analyzed data from 1,131 participants for cross-sectional analysis and 1,658 observations for longitudinal analysis.
Used linear mixed effects models to assess changes in DNA methylation associated with blood pressure changes.
Identified 59 DMPs associated with systolic blood pressure (SBP) and 60 DMPs for diastolic blood pressure (DBP).
204 DMPs were linked to hypertension, with a notable hypermethylated locus near GSE1 (OR = 0.014, 95% CI: 0.013, 0.015, p = 1.32×10-16).
Highlighted dynamic DNA methylation changes related to blood pressure over time, implicating several key genes and pathways.

Samson Okello (2026) studied this question.

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