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May 31, 2026Journal of Cardiovascular Development and DiseaseOpen Access

EATV was positively associated with total cardiovascular risk factor number (r = 0.51, p = 0.01), whereas EATD was negatively associated with total cardiovascular risk factor number (r = -0.40, p = 0.01).

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Why the study?

Are CT-derived epicardial adipose tissue volume and density associated with major cardiovascular disease risk factors in patients undergoing coronary CT angiography?

Population

105 participants examined with coronary computed tomography angiography.

Design

Cross-sectional

Authors

PGPaweł GaćPCPrzemysław CheładzeRPRafał Poręba

Discussion

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Overview

Greater exposure to major cardiovascular disease risk factors is associated with higher epicardial adipose tissue volume and lower density on CT, supporting its role as an imaging biomarker of cardiometabolic risk.

Key Points

  • This study aimed to evaluate the potential of EAT volume and density as markers reflecting cardiovascular disease risk factors.
  • Cross-sectional study with 105 participants examined via coronary computed tomography angiography.
  • EAT volume (EATV) and density (EATD) assessed using semi-automatic segmentation and manual corrections.
  • Clinical evaluation including anthropometric assessment, blood pressure measurement, and laboratory testing.
  • EAT volume was higher in men, and those with obesity, dyslipidemia, and type 2 diabetes.
  • EAT density was lower in participants with obesity, dyslipidemia, and type 2 diabetes.
  • Age, BMI, male gender, and dyslipidemia were independent risk factors for higher EAT volume, while dyslipidemia and type 2 diabetes were for lower EAT density.

Structured PICO

Are CT-derived epicardial adipose tissue volume and density associated with major cardiovascular disease risk factors in patients undergoing coronary CT angiography?

P
Population
105 participants (mean age: 62.12 ± 11.20 years; 58.1% women) examined with coronary computed tomography angiography.
O
Outcome
Epicardial adipose tissue volume (EATV) and epicardial adipose tissue density (EATD) measured by CT and their association with cardiovascular disease risk factors.surrogate

Greater exposure to major cardiovascular disease risk factors is associated with higher epicardial adipose tissue volume and lower density on CT, supporting its role as an imaging biomarker of cardiometabolic risk.

Cite This Study

Gać et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2ab5783ba022b6fe21ehttps://doi.org/10.3390/jcdd13060231
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