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May 30, 2026Journal of Clinical Oncology

Age-adjusted mortality rates for sudden cardiac death among older adults with hematologic malignancies in the US declined significantly from 1999 to 2023 (AAPC -1.98%; 95% CI -2.13 to -1.83; p<0.000001).

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Population

95,677 adults aged ≥65 years who died from sudden cardiac death associated with hematological malignancies…

Design

Cohort

Follow-up

1999 to 2023

Key result

Age-adjusted mortality rates for sudden cardiac death among older adults with hematologic malignancies in the US declined significantly from 1999 to 2023 (AAPC -1.98%; 95% CI -2.13 to -1.83; p<0.000001).

Authors

SNSteve Oguguo NwokeochaNFNoor FatimaHNHUZAIFA SABIR NAWAZ

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Overview

Sudden cardiac death mortality rates among older US adults with hematologic malignancies have significantly declined from 1999 to 2023, though the burden remains higher in men, Hispanic/Latino individuals, and the Northeast region.

Key Points

  • To examine national trends in sudden cardiac death (SCD) among older adults with hematologic malignancies in the U.S.
  • Analyzed death certificate data from the CDC WONDER database for adults aged ≥65 years from 1999 to 2023.
  • Defined SCD using ICD-10 codes and identified hematologic malignancies as the underlying cause of death.
  • Calculated age-adjusted and specific mortality rates and assessed trends using Joinpoint regression.
  • From 1999 to 2023, 95,677 adults aged ≥65 years died from SCD associated with hematological malignancies, with an AAMR decline from 11.69 to 6.76.
  • Age-adjusted mortality rates decreased significantly over the study period (AAPC: −1.98%; p < 0.000001).
  • Both men and women experienced significant declines, with major reductions observed across all racial and ethnic groups.

Study Design

Type

Observational (n=95,677)

Structured PICO

P
Population
95,677 adults aged ≥65 years who died from sudden cardiac death associated with hematological malignancies in the United States between 1999 and 2023.
O
Outcome
Age-adjusted and age-specific mortality rates per 100,000 persons for sudden cardiac death associated with hematologic malignancies, and temporal trends (annual percent change and average annual percent change).hard clinical

Main Result

Effect estimate: AAPC -1.98% (95% CI -2.13 to -1.83)

p-value: p=< 0.000001

Sudden cardiac death mortality rates among older US adults with hematologic malignancies have significantly declined from 1999 to 2023, though the burden remains higher in men, Hispanic/Latino individuals, and the Northeast region.

Cite This Study

Nwokeocha et al. (2026) conducted an observational in Sudden cardiac death associated with hematological malignancies (n=95,677). Age-adjusted mortality rates for sudden cardiac death among older adults with hematologic malignancies in the US declined significantly from 1999 to 2023 (AAPC -1.98%; 95% CI -2.13 to -1.83; p<0.000001).

synapsesocial.com/papers/6a1a814b0307b785094332fahttps://doi.org/10.1200/jco.2026.44.16_suppl.e18622
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