Population
US population with colorectal cancer mortality data from CDC WONDER, stratified by early-onset and late-onset
Design
Cohort
Follow-up
22 years (1999-2020)
Key result
US colorectal cancer mortality rates from 1999-2020 showed a continuous increase in adults ≤44 years (APC +0.78%; P=0.000001), contrasting with a decelerating decline in adults ≥45 years.
Authors
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While late-onset colorectal cancer mortality has declined, early-onset mortality has steadily increased by nearly 23% over the past two decades in the US, highlighting an emerging public health crisis.
Observational
Effect estimate: APC +0.78% (95% CI +0.54 to +1.02)
p-value: p=0.000001
While late-onset colorectal cancer mortality has declined, early-onset mortality has steadily increased by nearly 23% over the past two decades in the US, highlighting an emerging public health crisis.
Sharma et al. (2026) conducted an observational in Colorectal cancer. Early-onset (≤44 years) vs. Late-onset (≥45 years) was evaluated on Annual Percent Change (APC) in age-adjusted CRC mortality rates (APC +0.78%, 95% CI +0.54 to +1.02, p=0.000001). US colorectal cancer mortality rates from 1999-2020 showed a continuous increase in adults ≤44 years (APC +0.78%; P=0.000001), contrasting with a decelerating decline in adults ≥45 years.