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May 13, 2026IJTLD OPENOpen Access

Quality of life outcomes and patient-reported experiences in a randomised controlled trial for rifampicin-resistant TB (PRACTECAL-PRO): a mixed-methods study

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Authors

KLK. LowtonBSB. StringerMCM. Cusinato

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Overview

Randomized trial assesses quality of life and patient experiences in rifampicin-resistant TB, suggesting benefits of new treatments.

Key Points

  • Evaluate quality of life changes and patient experiences associated with new TB treatments compared to standard care.
  • Mixed-methods approach combining quantitative quality of life assessment and qualitative interviews.
  • Participants recruited from Belarus, Uzbekistan, and South Africa with a focus on QoL over 48 weeks.
  • QoL measured using SF-12 and SGRQ tools, with longitudinal analysis conducted.
  • All treatment groups showed improved scores on SF-12 and SGRQ after 48 weeks.
  • Investigational regimens displayed a greater proportional reduction in SGRQ scores compared to standard care for all domains.
  • Patient narratives indicated high satisfaction and the importance of social support for well-being.

Cite This Study

Lowton et al. (2026) studied this question.

synapsesocial.com/papers/6a0414cc79e20c90b4444adehttps://doi.org/10.5588/ijtldopen.25.0823
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