What question did this study set out to answer?

This research aims to refine the diagnostic classification of hypereosinophilia (HE) of persistent or unknown cause (HEPU) using bone marrow evaluations.

May 12, 2026American Journal of Clinical PathologyOpen Access

Hypereosinophilia of persistent/unknown cause: a bone marrow–based study integrating WHO-HAEM5 criteria and myeloid next-generation sequencing

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Authors

MEMOHAMED M. ELETREBIUniversity of Iowa JSJuan Sanchez-RamirezUniversity of Iowa AAAbdalla AbdallaUniversity of Iowa

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Implication

Randomized trial characterizes hypereosinophilia of unknown cause in patients, suggesting improved diagnostic clarity.

Key Points

This research aims to refine the diagnostic classification of hypereosinophilia (HE) of persistent or unknown cause (HEPU) using bone marrow evaluations.
Evaluated 307 bone marrow biopsy specimens from 2015 to 2023 mentioning eosinophilia.
Classified patients into groups based on defined etiologies and reviewed clinical data, morphology, and molecular tests.
Utilized WHO-HAEM5 criteria and International Consensus Classification for final diagnoses.
Patients with HEPU were significantly younger (median 48 vs 62 years; P = .004) and had higher eosinophil counts (2.8 vs 0.6 × 10^9/L; P < .001).
Most HEPU cases were reclassified: 36.8% idiopathic, 28.9% reactive eosinophilia, and 28.9% clonal disorders.
Myeloid next-generation sequencing detected mutations in 47% of tested HEPU patients, notably in genes such as TP53 and TET2.

Cite This Study

ELETREBI et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2fdce8c8c81e96405c8 https://doi.org/10.1093/ajcp/aqag031

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Hypereosinophilia of persistent/unknown cause: a bone marrow–based study integrating WHO-HAEM5 criteria and myeloid next-generation sequencing

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Cite This Study

Hypereosinophilia of persistent/unknown cause: a bone marrow–based study integrating WHO-HAEM5 criteria and myeloid next-generation sequencing

Discussion

Member takes

Implication

Key Points

Cite This Study

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