Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 15, 2026CureusOpen Access

Severe multi-valvular rheumatic heart disease presented with high rates of severe pulmonary hypertension (82%) and atrial fibrillation (58%), resulting in a 3.4% in-hospital mortality rate.

View Full Paper
Ask AI
Bookmark
Share

Key result

Severe multi-valvular rheumatic heart disease presented with high rates of severe pulmonary hypertension (82%) and atrial fibrillation (58%), resulting in a 3.4% in-hospital mortality rate.

Authors

SSShraiya StanABAnanjan Bhattacharya

Discussion

Loading...

Member takes

Overview

Retrospective analysis explores in-hospital outcomes in severe multi-valvular rheumatic heart disease, highlighting management challenges.

Key Points

  • The study aims to analyze clinical presentations, diagnostics, treatment strategies, and outcomes in patients with severe multi-valvular rheumatic heart disease.
  • Conducted a retrospective observational analysis of 385 patients with severe multi-valvular RHD admitted to two hospitals in New Delhi.
  • Reviewed clinical data, echocardiographic parameters, laboratory findings, and treatment protocols.
  • Analyzed in-hospital complication rates and follow-up outcomes over six months.
  • In-hospital mortality rate was 3.4% among the cohort, with a six-month mortality rate of 7.2%.
  • Major complications included atrial fibrillation in 58%, severe pulmonary hypertension in 82%, and right ventricular dysfunction in 69%.
  • Healthcare-associated infections affected 23% of the patients, with MRSA bacteremia present in 12%.

Study Design

Type

Observational (n=385)

Multicenter

Yes

PICO

P
Population
Severe multi-valvular rheumatic heart disease (n=385)
O
Primary Outcome
In-hospital mortality

Limitations

  • Used only descriptive statistics without inferential testing, regression modeling, or multivariable adjustment
  • Referral bias toward more severe and complex cases due to the specialized academic referral center setting
  • Selection bias introduced by the ≥7-day hospital stay inclusion criterion, which excluded milder cases and rapidly fatal cases
  • Incomplete six-month follow-up data (only 67% of discharged patients had available data)
  • Retrospective design limits data quality to medical record documentation and introduces recall bias for historical variables
  • Resource constraints in the public hospital setting may limit applicability to better-resourced healthcare systems

Cite This Study

Stan et al. (2026) conducted an observational in Severe multi-valvular rheumatic heart disease (n=385). Severe multi-valvular rheumatic heart disease presented with high rates of severe pulmonary hypertension (82%) and atrial fibrillation (58%), resulting in a 3.4% in-hospital mortality rate.

synapsesocial.com/papers/69df2cf7e4eeef8a2a6b20c4https://doi.org/10.7759/cureus.106946
View Full Paper
Ask AI
Bookmark
Share