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April 15, 2026European Heart Journal OpenOpen Access

Effect of high-intensity interval training on peak oxygen uptake, quality of life, and ventricular arrhythmias in patients with an implantable cardioverter defibrillator: a randomized controlled trial

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Authors

MNMathias NymanOMOle Christian MjølstadADAne Cecilie Dale

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Overview

Randomized controlled trial shows HIIT improves exercise capacity and quality of life in ICD patients, indicating potential benefits.

Key Points

  • This study aims to evaluate the impact of high-intensity interval training on peak oxygen uptake, quality of life, and ventricular arrhythmias in patients with an implantable cardioverter defibrillator.
  • 56 patients with coronary artery disease or non-ischemic dilated cardiomyopathy were randomized to a 12-week HIIT program or usual activity.
  • HIIT involved intervals at 85-95% of maximum heart rate.
  • Primary outcomes included changes in peak oxygen uptake and quality of life.
  • Secondary outcomes assessed changes in the burden of ventricular arrhythmias.
  • HIIT increased peak oxygen uptake by 7.0% compared to no change in the control group.
  • Quality of life improved in the HIIT group on the SF-36 health change domain after correction for multiple testing.
  • Sustained ventricular tachycardia incidence was lower in the HIIT group.
  • Concerns about exercise-induced arrhythmias were raised due to the small number of clinical events.

Cite This Study

Nyman et al. (2026) studied this question.

synapsesocial.com/papers/69df2c01e4eeef8a2a6b0f15https://doi.org/10.1093/ehjopen/oeag058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimal doses of high-intensity interval training in patients with coronary artery disease and heart failure: a systematic review and meta-analysis2026
  2. 2Pushing the limits: high-intensity training in cardiac rehabilitation - a single-center experience2026
  3. 3Long-Term Effects of High-Intensity Interval Training (HIIT) on Cardiac Function and Mortality in Heart Failure2025
  4. 4Time-Course of Physiological Adaptations to High-Intensity Interval Training-Based Cardiac Rehabilitation After Myocardial Infarction2026
  5. 5Effects of High-Intensity Interval Training on Cardiopulmonary Function in Patients with Acute Myocardial Infarction with and without Cardiac Arrest: A Retrospective Study2026