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April 15, 2026Cardio-OncologyOpen Access

Between 1999 and 2023, the overall AAMR for cardiac arrest and cancer-related mortality decreased from 37.3 to 21.1 per 100,000 individuals (AAPC -2.3, 95% CI -2.4 to -2.1, p < 0.001).

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Population

Adults in the United States with cardiac arrest and cancer-related mortality from 1999 to 2023.

Design

Cohort

Follow-up

1999 to 2023

Authors

RAReja AhmadMUMuhammad Salik UddinUAUrooj Amjad

Discussion

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Overview

Cardiac arrest and cancer-related mortality in the US decreased significantly from 1999 to 2023, though substantial demographic and geographic disparities persist, particularly affecting older adults, males, and non-Hispanic Black individuals.

Key Points

  • This research aims to analyze trends in cardiac arrest and cancer-related mortality in U.S. adults from 1999 to 2023, focusing on demographic differences.
  • Retrospective analysis of CDC WONDER data.
  • Calculated age-adjusted mortality rates (AAMR) and annual percentage changes (APC).
  • Utilized Joinpoint regression analysis to assess trends.
  • Overall AAMR decreased from 37.3 in 1999 to 21.1 in 2023.
  • Men had higher AAMRs than women, with notable declines for both sexes.
  • Significant disparities in AAMRs were observed by race and region.
  • The greatest decline occurred in middle-aged adults, especially in the South region.

Structured PICO

P
Population
Adults in the United States with cardiac arrest and cancer-related mortality from 1999 to 2023 (n=1,503,315 deaths).
O
Outcome
Age-adjusted mortality rates (AAMR) per 100,000 individuals and corresponding annual percentage changes (APC) for cardiac arrest and cancer-related mortalityhard clinical

Cardiac arrest and cancer-related mortality in the US decreased significantly from 1999 to 2023, though substantial demographic and geographic disparities persist, particularly affecting older adults, males, and non-Hispanic Black individuals.

Cite This Study

Ahmad et al. (2026) studied this question.

synapsesocial.com/papers/69df2a4be4eeef8a2a6af8a0https://doi.org/10.1186/s40959-026-00483-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in mortality from malignant neoplasms and cardiac arrest in the United States, 1999–2023.2026
  2. 2Abstract Fri147: The Weight of Risk: Epidemiological Trends in Cardiac Arrest Mortality Among Obese Adults in the United States (1999–2023)2025
  3. 3Shifting burden of cardiomyopathy deaths among United States cancer patients: A 25-year CDC WONDER analysis.2026
  4. 4Variations in Cancer with Heart Failure Related Mortality in the United States from 1999-20202025
  5. 5Trends and disparities in cardiomyopathy-associated mortality among breast cancer adults aged ≥45 years in the United States, 1999–2023: CDC WONDER analysis.2026