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April 14, 2026Journal of Cardiovascular ImagingOpen Access

Cardiotoxicity occurred in 30% of patients; independent predictors were LVGLS (aOR 1.33), LASr (aOR 0.77), and hs-TnI (aOR 1.07), with hs-TnI showing the highest discriminative ability (AUC 0.940).

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Why the study?

Does a multimodal surveillance strategy integrating LVGLS, LASr, and hs-TnI predict early anthracycline-induced cardiotoxicity in female breast cancer patients?

Population

50 female breast cancer patients treated with anthracycline-based chemotherapy, mean age 49.3 ± 8.5 years.

Design

Cohort

Follow-up

1 month after chemotherapy

Authors

AKAhmet Ferhat KayaMÖMehmet Özbek

Discussion

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Overview

A multimodal approach combining LVGLS, LASr, and hs-TnI effectively predicts early anthracycline-induced cardiotoxicity in breast cancer patients, with hs-TnI demonstrating the highest discriminative ability.

Key Points

  • To determine if a multimodal strategy using LVGLS, LASr, and hs-TnI can predict early cardiotoxicity from anthracycline chemotherapy.
  • Retrospective cohort study with 50 female breast cancer patients
  • Echocardiography and biomarkers assessed at baseline and one month post-chemotherapy
  • Cardiotoxicity defined as >10% reduction in LVEF to <53%
  • Cardiotoxicity occurred in 15 patients (30%)
  • All measured parameters (LVGLS, LASr, hs-TnI) significantly changed (P < 0.001)
  • hs-TnI demonstrated the highest ability to discriminate cardiotoxicity (AUC 0.940)

Structured PICO

Does a multimodal surveillance strategy integrating LVGLS, LASr, and hs-TnI predict early anthracycline-induced cardiotoxicity in female breast cancer patients?

P
Population
50 female breast cancer patients treated with anthracycline-based chemotherapy, mean age 49.3 ± 8.5 years.
I
Intervention
Multimodal surveillance strategy integrating left ventricular global longitudinal strain (LVGLS), left atrial reservoir strain (LASr), and high-sensitivity troponin I (hs-TnI) assessed at baseline and 1 month after chemotherapy.
O
Outcome
Early anthracycline-induced cardiotoxicity (defined as a > 10% reduction in LVEF to < 53%) at 1 month after chemotherapy.surrogate

A multimodal approach combining LVGLS, LASr, and hs-TnI effectively predicts early anthracycline-induced cardiotoxicity in breast cancer patients, with hs-TnI demonstrating the highest discriminative ability.

Cite This Study

Kaya et al. (2026) studied this question.

synapsesocial.com/papers/69ddda4de195c95cdefd7bbehttps://doi.org/10.1186/s44348-026-00071-y
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