What question did this study set out to answer?

This study aims to evaluate the incidence of ischemic stroke in patients with Takotsubo cardiomyopathy and identify associated risk factors.

April 14, 2026The Egyptian Heart JournalOpen Access

The pooled incidence of ischemic stroke was 4% (95% CI 0.01–0.06), and mortality risk was significantly higher in TC patients with ischemic stroke compared to those without (OR 7.57; 95% CI 2.70–21.22).

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Population

35,573 patients with Takotsubo cardiomyopathy from 6 studies (841 with ischemic stroke, 34,732 without).

Design

Meta-analysis

Authors

AIAleyda Zahratunany Insanitaqwa MAMaya Qurota A’yun FNFaizah Nadlirah

Discussion

Member takes

Overview

Ischemic stroke occurs in approximately 4% of Takotsubo cardiomyopathy patients and is associated with a significantly increased risk of mortality.

Key Points

This study aims to evaluate the incidence of ischemic stroke in patients with Takotsubo cardiomyopathy and identify associated risk factors.
Conducted a systematic review and meta-analysis of studies reporting ischemic stroke incidence in Takotsubo cardiomyopathy patients.
Performed comprehensive searches in multiple databases including PUBMED and ScienceDirect.
Assessed study quality using Joanna Briggs Institute Critical Appraisal Tools.
Utilized Review Manager and RStudio for statistical analyses.
Included six studies with 35,573 participants; 841 experienced ischemic stroke.
Pooled incidence of ischemic stroke was 4%, indicating significant health concern.
Patients with ischemic stroke had a 36% all-cause mortality rate, significantly higher than 3.12% in those without stroke.
Key risk factors identified include age, sex, diabetes, and atrial fibrillation.

Structured PICO

Population

35,573 patients with Takotsubo cardiomyopathy from 6 studies (841 with ischemic stroke, 34,732 without).

Comparator

Takotsubo cardiomyopathy patients without ischemic stroke

Outcome

Incidence of ischemic strokehard clinical

Ischemic stroke occurs in approximately 4% of Takotsubo cardiomyopathy patients and is associated with a significantly increased risk of mortality.

Cite This Study

Insanitaqwa et al. (2026) studied this question.

synapsesocial.com/papers/69ddda22e195c95cdefd79b2 https://doi.org/10.1186/s43044-026-00736-5

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April 14, 2026The Egyptian Heart JournalOpen Access

The pooled incidence of ischemic stroke was 4% (95% CI 0.01–0.06), and mortality risk was significantly higher in TC patients with ischemic stroke compared to those without (OR 7.57; 95% CI 2.70–21.22).

View Full Paper

Ask AI

Bookmark

Population

35,573 patients with Takotsubo cardiomyopathy from 6 studies (841 with ischemic stroke, 34,732 without).

Design

Meta-analysis

Authors

AIAleyda Zahratunany Insanitaqwa MAMaya Qurota A’yun FNFaizah Nadlirah

Discussion

Member takes

Overview

Ischemic stroke occurs in approximately 4% of Takotsubo cardiomyopathy patients and is associated with a significantly increased risk of mortality.

Key Points

This study aims to evaluate the incidence of ischemic stroke in patients with Takotsubo cardiomyopathy and identify associated risk factors.
Conducted a systematic review and meta-analysis of studies reporting ischemic stroke incidence in Takotsubo cardiomyopathy patients.
Performed comprehensive searches in multiple databases including PUBMED and ScienceDirect.
Assessed study quality using Joanna Briggs Institute Critical Appraisal Tools.
Utilized Review Manager and RStudio for statistical analyses.
Included six studies with 35,573 participants; 841 experienced ischemic stroke.
Pooled incidence of ischemic stroke was 4%, indicating significant health concern.
Patients with ischemic stroke had a 36% all-cause mortality rate, significantly higher than 3.12% in those without stroke.
Key risk factors identified include age, sex, diabetes, and atrial fibrillation.

Structured PICO

Population

35,573 patients with Takotsubo cardiomyopathy from 6 studies (841 with ischemic stroke, 34,732 without).

Comparator

Takotsubo cardiomyopathy patients without ischemic stroke

Outcome

Incidence of ischemic strokehard clinical

Ischemic stroke occurs in approximately 4% of Takotsubo cardiomyopathy patients and is associated with a significantly increased risk of mortality.

Cite This Study

Insanitaqwa et al. (2026) studied this question.

synapsesocial.com/papers/69ddda22e195c95cdefd79b2 https://doi.org/10.1186/s43044-026-00736-5

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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