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April 14, 2026European Heart Journal - Valvular and Structural Heart DiseaseOpen Access

CHD patients had a significantly higher risk of supraventricular (HR 8.0, 95% CI 7.6–8.5) and ventricular arrhythmias (HR 13.0, 95% CI 11.2–15.2) compared to controls, with lower risk observed in those born in 1990 or later.

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Why the study?

Does congenital heart disease increase the risk of arrhythmias compared to the general population, and how do temporal trends affect this risk?

Population

63,431 patients diagnosed with congenital heart disease born in 1970–2017 identified in the Swedish National…

Comparison

Congenital heart disease (exposure) vs Matched control subjects from the general…

Design

Cohort

Follow-up

median 19 years (range 0-53 years)

Authors

FEFilip EckerströmMDMikael DellborgWKWai Giang Kok

Discussion

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Overview

Patients with congenital heart disease have a markedly increased risk of both supraventricular and ventricular arrhythmias compared to the general population, although this risk has decreased for those born in 1990 or later.

Key Points

  • This research aims to explore the burden and trends of arrhythmias in patients with congenital heart disease over time.
  • Identified 63,431 patients with congenital heart disease from a national registry.
  • Matched patients by age and sex with 583,100 controls from the general population.
  • Used Fine–Gray competing risk and Cox proportional-hazards regression to calculate risk estimates.
  • 1,895 new supraventricular arrhythmias observed with a hazard ratio of 8.0.
  • 371 new ventricular arrhythmias with a hazard ratio of 13.0.
  • Patients born in 1990 or later had a significantly lower risk for both arrhythmias compared to those born before 1990.

Structured PICO

Does congenital heart disease increase the risk of arrhythmias compared to the general population, and how do temporal trends affect this risk?

P
Population
63,431 patients diagnosed with congenital heart disease (CHD) born in 1970–2017 identified in the Swedish National Patient Register, matched by age and sex with 583,100 control subjects from the general population.
I
Intervention
Congenital heart disease (exposure)
C
Comparator
Matched control subjects from the general population
O
Outcome
New events of supraventricular arrhythmias and ventricular arrhythmiashard clinical

Patients with congenital heart disease have a markedly increased risk of both supraventricular and ventricular arrhythmias compared to the general population, although this risk has decreased for those born in 1990 or later.

Cite This Study

Eckerström et al. (2026) studied this question.

synapsesocial.com/papers/69ddd938e195c95cdefd68cdhttps://doi.org/10.1093/ehjvshd/xwag029
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