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April 13, 2026Vascular and Endovascular Surgery

Survival was 97% at 48 hours and 95% at 6 months, with significant reductions in mean sPAP (P < .001) and increases in TAPSE (P < .001).

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Why the study?

Does a triple percutaneous treatment protocol involving mechanical thrombolysis, aspiration, and low-dose tPA improve survival and right ventricular function in patients with moderate to high or high-risk pulmonary embolism?

Population

35 adults (aged ≥18 years) with moderate to high or high-risk pulmonary embolism, mean age 55, 51.43% male.

Design

Cohort

Follow-up

6 months

Authors

CTCarlos Torres-HerreraRGRuvistay Gutiérrez-AriasRLRubén Lamich

Discussion

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Overview

A triple percutaneous treatment protocol combining mechanical thrombolysis, aspiration, and low-dose tPA appears safe and effective for moderate to high-risk pulmonary embolism, yielding high survival and improved right ventricular function.

Key Points

  • To assess clinical outcomes and safety of a triple treatment protocol for moderate to high-risk pulmonary embolism.
  • Retrospective cohort design
  • Included patients aged 18 and older with moderate to high-risk PE
  • Primary outcome measured was survival
  • Secondary outcomes included functional capacity, pulmonary arterial pressure, RV dilation
  • Outcomes assessed at 48 hours and 6 months post-procedure.
  • Survival rate at 48 hours was 97%
  • 95% survival at 6-month follow-up
  • Functional capacity improved from 23% to 100% at 6 months
  • RV dilation improved from 71% at admission to 100% at 6 months
  • Significant reduction in systolic pulmonary artery pressure to 29 mmHg at 6 months

Structured PICO

Does a triple percutaneous treatment protocol involving mechanical thrombolysis, aspiration, and low-dose tPA improve survival and right ventricular function in patients with moderate to high or high-risk pulmonary embolism?

P
Population
35 adults (aged ≥18 years) with moderate to high or high-risk pulmonary embolism, mean age 55, 51.43% male.
I
Intervention
Triple percutaneous treatment protocol involving mechanical thrombolysis, direct thromboaspiration, and low-dose tPA thrombolysis.
O
Outcome
Survivalhard clinical

A triple percutaneous treatment protocol combining mechanical thrombolysis, aspiration, and low-dose tPA appears safe and effective for moderate to high-risk pulmonary embolism, yielding high survival and improved right ventricular function.

Cite This Study

Torres-Herrera et al. (2026) studied this question.

synapsesocial.com/papers/69dc88583afacbeac03ea3a3https://doi.org/10.1177/15385744261441952
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness and Safety of Reduced-Dose and Slow-Infusion Intravenous Tissue-Type Plasminogen Activator Regimen in Patients with Acute Pulmonary Embolism at Intermediate-High Risk2025 · 2 citations
  2. 2Periprocedural Results and Right Ventricular Outcomes of Computer Assisted Vacuum Thrombectomy Treatment of Acute Pulmonary Embolism: Interim Analysis of 300 Patients From the STRIKE‐PE Study2025 · 1 citations
  3. 3Ultrasound Images That Speak: Assessing the Therapeutic Decision in the Emergency Department Regarding the Risk–Benefit Ratio of Systemic Thrombolysis in Intermediate-High-Risk Pulmonary Embolism—A Case Report2025
  4. 4Clinical Outcomes Following Mechanical Thrombectomy in Pulmonary Embolism Response Team-Consulted Patients: A Retrospective Analysis2025 · 1 citations
  5. 5Role of early catheter-based interventions in acute pulmonary embolism: a case report2025