What question did this study set out to answer?

This study assesses the predictive value of CTPA parameters combined with D-dimer for risk stratification and 30-day prognosis in acute pulmonary embolism.

April 13, 2026SHILAP Revista de lepidopterologíaOpen Access

Prognostic utility of combined 256-detector-row computed tomographic pulmonary angiography and D-dimer in risk stratification of acute pulmonary embolism: a retrospective cohort analysis

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Why the study?

Does the combination of CTPA-derived RVD/LVD ratio and D-dimer levels improve risk stratification and 30-day prognostic assessment in patients with acute pulmonary embolism?

Key Points

This study assesses the predictive value of CTPA parameters combined with D-dimer for risk stratification and 30-day prognosis in acute pulmonary embolism.
Retrospective cohort study design with 77 patients diagnosed with acute pulmonary embolism.
Assessment of clinical characteristics, CTPA-derived metrics, and serum D-dimer levels.
Receiver operating characteristic curve analysis and multivariate logistic regression were utilized for predictive performance.
Bilateral pulmonary embolism incidence escalated from 44.7% in low-risk to 87.5% in high-risk groups.
RVD/LVD ratio showed significant correlation with risk stratification (p < 0.001) and median values differed across groups.
D-dimer levels increased significantly with risk stratification and effectively differentiated patients from controls (p < 0.001).
Combined model with RVD/LVD and D-dimer achieved AUC of 0.917 for predicting high-risk APE.

Structured PICO

Does the combination of CTPA-derived RVD/LVD ratio and D-dimer levels improve risk stratification and 30-day prognostic assessment in patients with acute pulmonary embolism?

Population

166 individuals, including 77 patients with acute pulmonary embolism (APE) (stratified into low-risk n=38, intermediate-low-risk n=17, intermediate-high-risk n=14, high-risk n=8) and 89 control individuals, treated at Baoshan People’s Hospital.

Intervention

Combined 256-detector-row computed tomographic pulmonary angiography (CTPA) parameters (specifically RVD/LVD ratio) and serum D-dimer levels

Comparator

Individual indicators (RVD/LVD alone or D-dimer alone)

Outcome

Risk stratification and 30-day prognostic assessment (predicting high-risk APE and poor short-term prognosis)surrogate

Limitations

single-center retrospective design
limited sample size

Discussion

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Implication

The integration of CTPA-derived RVD/LVD ratio with D-dimer levels significantly improves risk stratification and short-term prognostic assessment in patients with acute pulmonary embolism.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69dc874a3afacbeac03e9c56 https://doi.org/10.3389/fphys.2026.1796105

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Implication

The integration of CTPA-derived RVD/LVD ratio with D-dimer levels significantly improves risk stratification and short-term prognostic assessment in patients with acute pulmonary embolism.

Prognostic utility of combined 256-detector-row computed tomographic pulmonary angiography and D-dimer in risk stratification of acute pulmonary embolism: a retrospective cohort analysis

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Prognostic utility of combined 256-detector-row computed tomographic pulmonary angiography and D-dimer in risk stratification of acute pulmonary embolism: a retrospective cohort analysis

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider