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April 12, 2026NMR in BiomedicineOpen Access

Heterogeneous Myocardial Adaptation to Pressure Overload Reveals a Spared, Vulnerable Segment Identified by Multiparametric Cardiac MRI

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Population

37 male 129/SvEv mice

Design

Preclinical

Follow-up

7 weeks

Key result

Left ventricular segments failing to hypertrophy during pressure overload in 49% of subjects exhibited reduced fractional shortening (10.2% vs 24.9%) and lower ejection fraction (32.5% vs 49.8%).

Authors

VKVitali KochAOAndreas OchsSMSimon S. Martin

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Overview

Multiparametric MRI demonstrates that heterogeneous myocardial adaptation to pressure overload, specifically the failure of certain segments to hypertrophy, is linked to early regional and global ventricular dysfunction.

Key Points

  • The aim is to map adaptation patterns of the left ventricle under pressure overload, focusing on regional differences.
  • Thirty-seven male mice underwent transverse aortic constriction (TAC) surgery.
  • High-resolution multiparametric cardiac MRI was used to analyze the left ventricle at multiple time points.
  • Quantitative analysis of wall thickness, fractional shortening and relaxation times
  • Statistical analyses employed Mann-Whitney test and correlation modeling.
  • All TAC animals developed global left ventricular hypertrophy and increased LV mass (+62% at Week 7).
  • In 49% of animals, a basolateral LV segment showed spared hypertrophy despite increased pressure.
  • Spared hypertrophy regions had reduced fractional shortening (10.2% vs. 24.9%) and lower ejection fraction (32.5% vs. 49.8%).
  • T1 values increased in hypertrophied sectors but decreased in spared hypertrophy sectors, indicating maladaptive remodeling.

Structured PICO

P
Population
37 male 129/SvEv mice
I
Intervention
Transverse aortic constriction (TAC) surgery
O
Outcome
Regional and temporal adaptation patterns of the left ventricle (LV) including wall thickness, fractional shortening (FS), and relaxation times measured by multiparametric cardiac MRIsurrogate

Multiparametric MRI demonstrates that heterogeneous myocardial adaptation to pressure overload, specifically the failure of certain segments to hypertrophy, is linked to early regional and global ventricular dysfunction.

Cite This Study

Koch et al. (2026) studied this question. Left ventricular segments failing to hypertrophy during pressure overload in 49% of subjects exhibited reduced fractional shortening (10.2% vs 24.9%) and lower ejection fraction (32.5% vs 49.8%).

synapsesocial.com/papers/69db37f94fe01fead37c60f3https://doi.org/10.1002/nbm.70288
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