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April 12, 2026Frontiers in Bioengineering and BiotechnologyOpen Access

AS-IV@HdECM hydrogel reduced myocardial infarct size to 15.4% and significantly improved cardiac function and microvascular regeneration in a rat myocardial infarction model.

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Why the study?

Does intrapericardial delivery of Astragaloside IV via a heart-derived extracellular matrix hydrogel improve microvascular regeneration and cardiac repair in a rat model of myocardial infarction?

Population

Rat myocardial infarction (MI) model and in vitro endothelial cells under oxygen-glucose deprivation

Design

Preclinical

Key result

AS-IV@HdECM hydrogel reduced myocardial infarct size to 15.4% and significantly improved cardiac function and microvascular regeneration in a rat myocardial infarction model.

Authors

YLYanxing LanZXZijun XuYLYajing Li

Discussion

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Overview

A novel heart-derived extracellular matrix hydrogel delivering Astragaloside IV intrapericardially promotes microvascular regeneration and cardiac repair in a preclinical myocardial infarction model.

Key Points

  • To explore the effectiveness of a heart-derived hydrogel for delivering Astragaloside IV to enhance microvascular regeneration after myocardial infarction.
  • Development of a heart-specific extracellular matrix hydrogel
  • Intrapericardial delivery of Astragaloside IV
  • Evaluation of endothelial cell survival, migration, and angiogenic capacity
  • Use of a rat myocardial infarction model
  • Proteomic and network pharmacology analyses for mechanism exploration.
  • AS-IV@HdECM hydrogel enhances endothelial cell survival and migration
  • Promotes neovascularization in the rat model
  • Reduces myocardial fibrosis and cardiomyocyte apoptosis
  • Significantly improves cardiac function
  • Therapeutic effects linked to activation of the EGFR/Raf–MEK–ERK signaling pathway.

Structured PICO

Does intrapericardial delivery of Astragaloside IV via a heart-derived extracellular matrix hydrogel improve microvascular regeneration and cardiac repair in a rat model of myocardial infarction?

P
Population
Rat myocardial infarction (MI) model and in vitro endothelial cells under oxygen-glucose deprivation
I
Intervention
Intrapericardial delivery of Astragaloside IV (AS-IV) via decellularized porcine heart extracellular matrix (HdECM) hydrogel
O
Outcome
Neovascularization, myocardial fibrosis, cardiomyocyte apoptosis, and cardiac functionsurrogate

A novel heart-derived extracellular matrix hydrogel delivering Astragaloside IV intrapericardially promotes microvascular regeneration and cardiac repair in a preclinical myocardial infarction model.

Cite This Study

Lan et al. (2026) studied Myocardial infarction. AS-IV@HdECM hydrogel vs. PBS (MI control), HdECM hydrogel alone, AS-IV alone was evaluated on Infarct size. AS-IV@HdECM hydrogel reduced myocardial infarct size to 15.4% and significantly improved cardiac function and microvascular regeneration in a rat myocardial infarction model.

synapsesocial.com/papers/69db35be4fe01fead37c43a0https://doi.org/10.3389/fbioe.2026.1800990
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Also Consider

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  1. 1An injectable SFMA/HA-E hydrogel for sustained delivery of hucMSC-derived exosomes promotes myocardial repair after infarction2026
  2. 2Molecular Mechanisms of Myocardial Repair and Cardiac Function Improvement With Hydrogel‐Mediated Macrophage‐Derived Exosome Delivery2025
  3. 3Myocardial Infarction Treatment with a Composite Hydrogel Containing Metformin-Induced Vesicles of Adipose-Derived Stem Cells2026
  4. 4Stromal Cell-Derived Factor-1α Activation of Tissue-Engineered Endothelial Progenitor Cell Matrix Enhances Ventricular Function After Myocardial Infarction by Inducing Neovasculogenesis2010 · 90 citations
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