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April 10, 2026Catheterization and Cardiovascular InterventionsOpen Access

Heart failure with reduced ejection fraction affects one in nine LAAO patients and is associated with higher risks of major in-hospital complications and readmission.

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Why the study?

Does the presence of HFrEF increase the risk of major in-hospital complications and hospital readmission in patients undergoing LAAO?

Population

Patients treated with Left Atrial Appendage Occlusion (LAAO) in the United States

Design

Cohort

Key result

Heart failure with reduced ejection fraction affects one in nine LAAO patients and is associated with higher risks of major in-hospital complications and readmission.

Authors

AUAamer UbaidABArindam BaggaKKKevin Kennedy

Discussion

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Member takes

Overview

HFrEF is a significant risk factor for in-hospital complications and readmissions in patients undergoing LAAO.

Key Points

  • This research investigates the outcomes of left atrial appendage occlusion in patients with heart failure with reduced ejection fraction.
  • Analyzed data from patients treated with left atrial appendage occlusion (LAAO)
  • Identified incidence of complications and hospital readmissions relative to heart failure status
  • One out of nine patients undergoing LAAO has heart failure with reduced ejection fraction (HFrEF)
  • HFrEF patients face a higher risk of major in-hospital complications
  • Increased readmission rates observed in HFrEF patients post-LAAO

Structured PICO

Does the presence of HFrEF increase the risk of major in-hospital complications and hospital readmission in patients undergoing LAAO?

P
Population
Patients treated with Left Atrial Appendage Occlusion (LAAO) in the United States
I
Intervention
Left Atrial Appendage Occlusion (LAAO) in patients with Heart Failure with Reduced Ejection Fraction (HFrEF)
O
Outcome
Major in-hospital complications and hospital readmissionhard clinical

HFrEF is a significant risk factor for in-hospital complications and readmissions in patients undergoing LAAO.

Cite This Study

Ubaid et al. (2026) studied this question. Heart failure with reduced ejection fraction affects one in nine LAAO patients and is associated with higher risks of major in-hospital complications and readmission.

synapsesocial.com/papers/69d895796c1944d70ce06747https://doi.org/10.1002/ccd.70607
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Atrial Appendage Occlusion: Real World Observational Data on In-Hospital Results, Clinical Outcome and Hemoglobin Level2025
  2. 2Clinical Outcomes of Left Atrial Appendage Occlusion in Patients with Hyperlipidemia: A Nationwide Analysis2025
  3. 3Left Atrial Appendage Occlusion Devices Focused on Complications of Therapy2025
  4. 4Severe Orthostatic Hypotension Following Left Atrial Appendage Occlusion2026
  5. 5Percutaneous left atrial appendage closure in non-valvular atrial fibrillation with concomitant heart failure: a systematic review and meta-analysis of periprocedural and long-term outcomes2026