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January 24, 2026eLifeOpen Access

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

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Key result

The TTN-T32756I missense variant is linked to worse clinical outcomes and drives atrial fibrillation through altered cardiac potassium channel activity and calcium dysregulation.

Authors

MPMahmud Arif PavelHCHanna ChenMHMichael Hill

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Cite This Study

Pavel et al. (2026) studied this question. The TTN-T32756I missense variant is linked to worse clinical outcomes and drives atrial fibrillation through altered cardiac potassium channel activity and calcium dysregulation.

synapsesocial.com/papers/697565c5d5e0d64addde7f12https://doi.org/10.7554/elife.104719.3
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  1. 1Titin Missense Variants as a Cause of Familial Dilated Cardiomyopathy2023 · 25 citations