January 9, 2026International Journal of Cardiology

Impaired myocardial work in heart failure with improved ejection fraction: A post hoc analysis from the CATHEDRAL-HF trial

View Full Paper

Ask AI

Bookmark

Key result

Suspension of heart failure treatment while maintaining carvedilol did not change myocardial work components in patients with heart failure and improved ejection fraction.

Authors

DBDeborah de Sá Pereira Belfort DFDiógenes Amauri Gonçalves FurlanUniversidade de São Paulo CCCaio Rebouças Fonseca CafezeiroUniversidade de São Paulo

Discussion

Member takes

Implication

A post hoc analysis examines myocardial work in heart failure with improved ejection fraction, showing persistent dysfunction despite normal ejection fraction.

Key Points

This analysis aims to describe myocardial work in heart failure with improved ejection fraction and its changes following treatment suspension.
Randomized clinical trial comparing maintenance carvedilol versus usual heart failure treatment.
Participants with heart failure and improved ejection fraction were evaluated at baseline and after 24 weeks.
Myocardial work components were measured and analyzed at both time points.
Sixty patients were enrolled, with median ejection fraction at 59%.
Global Work Waste increased while Global Work Index and Efficiency decreased in both groups compared to normal ranges.
At 24 weeks, myocardial work components remained unchanged between groups, indicating persistent LV dysfunction.

Cite This Study

Belfort et al. (2025) studied this question. Suspension of heart failure treatment while maintaining carvedilol did not change myocardial work components in patients with heart failure and improved ejection fraction.

synapsesocial.com/papers/696135ac766f0a95ea6ade65 https://doi.org/10.1016/j.ijcard.2025.134120

View Full Paper

Ask AI

Bookmark

Implication

A post hoc analysis examines myocardial work in heart failure with improved ejection fraction, showing persistent dysfunction despite normal ejection fraction.