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January 9, 2026Lipids in Health and DiseaseOpen Access

The modified cardiometabolic index (MCMI) had a stronger association with incident type 2 diabetes (HR 6.25) than the triglyceride-glucose index (HR 3.76) over 12 years.

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Key result

The modified cardiometabolic index (MCMI) had a stronger association with incident type 2 diabetes (HR 6.25) than the triglyceride-glucose index (HR 3.76) over 12 years.

Authors

WGWei GeCSChenjie SunZZZhijian Zhu

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Overview

Longitudinal cohort study compares modified cardiometabolic index and triglyceride-glucose index in predicting type 2 diabetes, suggesting improved screening techniques.

Key Points

  • This study aims to evaluate the predictive performance of the modified cardiometabolic index for type 2 diabetes incidence compared to the triglyceride-glucose index in a normoglycemic cohort.
  • Conducted a longitudinal cohort study over 12 years with 15,453 adults at normal baseline glucose levels.
  • Utilized Cox regression models and restricted cubic spline analysis to examine associations.
  • Evaluated predictive performance using receiver operating characteristic analysis.
  • Out of 15,453 participants, 373 (2.41%) developed type 2 diabetes during the follow-up period.
  • The modified cardiometabolic index had a higher hazard ratio (HR 6.25) for diabetes incidence compared to the triglyceride-glucose index (HR 3.76).
  • The modified cardiometabolic index maintained superior predictive performance across different subgroups.

Cite This Study

Ge et al. (2025) studied this question. The modified cardiometabolic index (MCMI) had a stronger association with incident type 2 diabetes (HR 6.25) than the triglyceride-glucose index (HR 3.76) over 12 years.

synapsesocial.com/papers/69612fe730ef6c21f6853fbbhttps://doi.org/10.1186/s12944-025-02839-5
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