What question did this study set out to answer?

To explore the association between female reproductive factors and the risk of incident cardiometabolic diseases in women.

January 9, 2026Global HeartOpen Access

Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study

View Full Paper

Ask AI

Bookmark

Key result

Menarche after age 13 years, earlier menopause, shorter reproductive lifespan, and higher parity increase cardiometabolic disease risk among women.

Authors

CWChangxi WangFujian Medical University ZLZhijie LinFujian Medical University FCFan ChenHenan Polytechnic University

Discussion

Member takes

Implication

Population-based analysis shows reproductive factors influence cardiometabolic disease risk in women, suggesting new screening opportunities.

Key Points

To explore the association between female reproductive factors and the risk of incident cardiometabolic diseases in women.
Analyzed data from 189,411 women in the UK Biobank without prior cardiometabolic diseases.
Followed participants from 2007 until December 2022.
Used Cox proportional hazards models to assess relationships between reproductive factors and cardiometabolic disease, adjusting for confounders.
17,251 incident cardiometabolic disease events occurred over a median follow-up of 13.2 years.
Menarche age less than 12 or greater than 13 years associated with higher risk (HR 1.04 and 1.08 respectively, compared to 12-13 years).
Younger age at menopause linked to increased risk (HR 1.22 for <46 years).
Shorter reproductive lifespan correlated with higher risk, particularly for those under 33 years (HR 1.19).
Having three or more children increases CMD risk, with HRs of 1.21 for three or four children and 1.27 for more than four.

Cite This Study

Wang et al. (2025) studied this question. Menarche after age 13 years, earlier menopause, shorter reproductive lifespan, and higher parity increase cardiometabolic disease risk among women.

synapsesocial.com/papers/69612fe130ef6c21f6853ece https://doi.org/10.5334/gh.1509

View Full Paper

Ask AI

Bookmark

Implication

Population-based analysis shows reproductive factors influence cardiometabolic disease risk in women, suggesting new screening opportunities.

Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider