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January 9, 2026International Journal of Molecular SciencesOpen Access

Lp(a) in the Horizon of Diagnostics and Therapy

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Key result

Elevated lipoprotein(a) levels are an independent risk factor for atherosclerotic cardiovascular disease, particularly in premature events, underscoring the need for routine measurement.

Authors

PFPietro FormisanoFederico II University Hospital EVElena Vianello EDElena DozioUniversity of Milan

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Implication

Minireview discusses Lp(a) as a crucial cardiovascular risk marker, emphasizing standardized measurement and implications for therapy.

Key Points

This research aims to clarify the role of Lp(a) in cardiovascular risk assessment and its potential in treatment strategies.
Literature review of pathophysiological mechanisms of Lp(a) and its clinical implications.
Discussion of historical challenges in Lp(a) measurement and the need for standardized assays.
Analysis of emerging Lp(a)-targeted therapies and their potential benefits.
Elevated Lp(a) levels are linked to a higher incidence of cardiovascular events, regardless of LDL-C levels.
Distinct mechanisms of Lp(a) contribute to cardiovascular diseases, not captured by traditional lipid profiles.
Standardized measurements of Lp(a) could enhance risk assessment and treatment protocols.

Cite This Study

Formisano et al. (2025) studied this question. Elevated lipoprotein(a) levels are an independent risk factor for atherosclerotic cardiovascular disease, particularly in premature events, underscoring the need for routine measurement.

synapsesocial.com/papers/69612fe130ef6c21f6853ec2 https://doi.org/10.3390/ijms27010290

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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

1Oxidized Phospholipids on Apo B2025 · 4 citations
2Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease2009 · 1,697 citations